Table 7 Consensus P. mirabilis-SCDR1 antibiotic Resistome
Source | Source Organism | Gene | Product | Function | Query Coverage | Identity | E-value |
|---|---|---|---|---|---|---|---|
ARDB | P. mirabilis ATCC 29906 | tetAJ | Tetracycline efflux protein TetA | Major facilitator superfamily transporter, tetracycline efflux pump. | 97 | 95 | 0 |
CARD | P. mirabilis BB2000 | tetAJ | Tetracycline efflux protein TetA | Major facilitator superfamily transporter, tetracycline efflux pump. | 97 | 94 | 0 |
ARDB | P. mirabilis HI4320 | tetAJ | Tetracycline efflux protein TetA | Major facilitator superfamily transporter, tetracycline efflux pump. | 80 | 99 | 2e-74 |
CARD | P. mirabilis BB2000 | gyrA | DNA gyrase subunit A (EC 5.99.1.3) | Point mutation of Escherichia coli gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance | 98 | 99 | 0 |
CARD | P. mirabilis BB2000 | baeR | Response regulator BaeR | BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes. | 100 | 99 | 2e-171 |
CARD | P. mirabilis BB2000 | baeS | Sensory histidine kinase BaeS | BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity. | 100 | 99 | 0 |
CARD | P. mirabilis BB2000 | mdtC | Multidrug transporter MdtC | MdtC is a transporter that forms a hetero-multimer complex with MdtB to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex. | 100 | 99 | 0 |
CARD | P. mirabilis BB2000 | mdtB | Multidrug transporter MdtB | MdtB is a transporter that forms a heteromultimer complex with MdtC to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex. | 100 | 99 | 0 |
CARD | P. mirabilis BB2000 | mdtA | RND efflux system, membrane fusion protein | MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC. | 100 | 98 | 0 |
CARD | P. mirabilis BB2000 | folP | Dihydropteroate synthase (EC 2.5.1.15) | Point mutations in dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance. | 100 | 100 | 0 |
CARD | P. mirabilis BB2000 | soxR | Redox-sensitive transcriptional activator SoxR | SoxR is a sensory protein that upregulates soxS expression in the presence of redox-cycling drugs. This stress response leads to the expression many multidrug efflux pumps. | 100 | 100 | 0 |
CARD | Shigella dysenteriae Sd197 | ompR | Two-component system response regulator OmpR | Transcriptional regulatory protein | 99 | 87 | 0 |
CARD | P. mirabilis BB2000 | emrR | Transcriptional repressor MprA | EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. | 100 | 100 | 0 |
CARD | P. mirabilis BB2000 | emrA | Multidrug resistance protein ErmA | EmrA is a membrane fusion protein, providing an efflux pathway with EmrB and TolC between the inner and outer membranes of E. coli, a Gram-negative bacterium. | 95 | 96 | 0 |
CARD | P. mirabilis BB2000 | acrE | Membrane fusion component of tripartite multidrug resistance system | AcrEF-TolC is a tripartite multidrug efflux system similar to AcrAB-TolC and found in Gram-negative bacteria. AcrE is the membrane fusion protein, AcrF is the inner membrane transporter, and TolC is the outer membrane channel protein. | 100 | 98 | 3e-44 |
CARD | P. mirabilis BB2000 | emrB | Multidrug resistance protein ErmB | emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP), nalidixic acid, and thioloactomycin. | 100 | 99 | 0 |
CARD | P. mirabilis BB2000 | rpoB | DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) | Mutations in rpoB gene confers antibiotic resistance (Daptomycin and Rifamycin) | 100 | 99 | 0 |
CARD | P. mirabilis BB2000 | tufB | Translation elongation factor Tu | Sequence variants of elongation factor Tu confer resistance to elfamycin antibiotics. | 100 | 100 | 1e-43 |
CARD | P. mirabilis BB2000 | cpxA | Copper sensory histidine kinase CpxA | cpxA mutant confer resistant to amikacin | 94 | 99 | 0 |
CARD | P. mirabilis BB2000 | cpxR | Copper-sensing two-component system response regulator CpxR | CpxR is a regulator that promotes acrD expression when phosphorylated by a cascade involving CpxA, a sensor kinase. Cefepime and chloramphenicol | 100 | 100 | 0 |
CARD | P. mirabilis BB2000 | emrD | Multidrug resistance protein D | EmrD is a multidrug transporter from the Major Facilitator Superfamily (MFS) primarily found in Escherichia coli. EmrD couples efflux of amphipathic compounds with proton import across the plasma membrane. | 100 | 99 | 0 |
CARD | P. mirabilis BB2000 | macA | Macrolide-specific efflux protein MacA | MacA is a membrane fusion protein that forms an antibiotic efflux complex with MacB and TolC. | 100 | 99 | 3e-177 |
CARD | P. mirabilis BB2000 | macB | Macrolide export ATP-binding/permease protein MacB (EC 3.6.3.-) | MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC. | 100 | 98 | 0 |
ARDB | P. mirabilis ATCC 29906 | cat | Chloramphenicol acetyltransferase (EC 2.3.1.28) | Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol. | 99 | 93 | 6e-150 |
CARD | P. mirabilis BB2000 | cat | Chloramphenicol acetyltransferase (EC 2.3.1.28) | Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol. | 99 | 93 | 4e-151 |
CARD | P. mirabilis BB2000 | acrR | Transcription repressor of multidrug efflux pump acrAB operon, TetR (AcrR) family | AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance. | 100 | 95 | 9e-25 |
CARD | P. mirabilis BB2000 | acrR | Transcriptional regulator of acrAB operon, AcrR | AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance. | 93 | 95 | 2e-114 |
CARD | P. mirabilis BB2000 | acrA | RND efflux system, membrane fusion protein | Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrA represents the periplasmic portion of the transport protein. | 100 | 99 | 0 |
CARD | P. mirabilis BB2000 | mdtK | Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps | A multidrug and toxic compound extrusions (MATE) transporter conferring resistance to norfloxacin, doxorubicin and acriflavine. | 98 | 99 | 3e-164 |
CARD | Salmonella enterica subsp. enterica serovar Agona str. SL483 | hns | DNA-binding protein H-NS | H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE, mdtE, and emrK as well as nearby genes of many RND-type multidrug exporters. | 100 | 80 | 0 |
CARD | P. mirabilis BB2000 | tufB | Translation elongation factor Tu | Sequence variants of elongation factor Tu confer resistance to elfamycin antibiotics. | 100 | 99 | 0 |
CARD | Shigella dysenteriae Sd197 | crp | Cyclic AMP receptor protein | CRP is a global regulator that represses MdtEF multidrug efflux pump expression. | 100 | 98 | 0 |
CARD | P. mirabilis BB2000 | emrE | Ethidium bromide-methyl viologen resistance protein EmrE | EmrE is a small multidrug transporter that functions as a homodimer and that couples the efflux of small polyaromatic cations from the cell with the import of protons down an electrochemical gradient. EmrE is found in E. coli and P. aeruginosa. | 100 | 99 | 6e-73 |
CARD | P. mirabilis BB2000 | mdtK | Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps | A multidrug and toxic compound extrusions (MATE) transporter conferring resistance to norfloxacin, doxorubicin and acriflavine. | 100 | 100 | 2e-113 |
CARD | P. mirabilis BB2000 | NIA | Putative transport protein | NIA | 100 | 94 | 7e-59 |
CARD | P. mirabilis BB2000 | NIA | Multidrug resistance protein | NIA | 99 | 96 | 2e-112 |
CARD | P. mirabilis BB2000 | parC | Topoisomerase I subunit A (EC 5.99.1.-) | ParC is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Point mutations in ParC prevent fluoroquinolone antibiotics from inhibiting DNA synthesis, and confer low-level resistance. Higher-level resistance results from both gyrA and parC mutations. | 99 | 99 | 0 |
CARD | P. mirabilis BB2000 | parE | Topoisomerase IV subunit B (EC 5.99.1.-) | ParE is a subunit of topoisomerase IV, necessary for cell survival. Point mutations in ParE prevent fluoroquinolones from inhibiting DNA synthesis, thus conferring resistance. | 100 | 99 | 0 |
CARD | P. mirabilis BB2000 | tolC | Type I secretion outer membrane protein, TolC precursor | TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex. | 100 | 99 | 0 |
CARD | P. mirabilis BB2000 | mdtH | MFS superfamily export protein YceL | Multidrug resistance protein MdtH | 100 | 99 | 0 |
CARD | P. mirabilis BB2000 | phoP | Transcriptional regulatory protein PhoP | A mutant phoP activates pmrHFIJKLM expression responsible for L-aminoarabinose synthesis and polymyxin resistance, by way of alteration of negative charge | 100 | 99 | 5e-165 |
CARD | P. mirabilis BB2000 | phoQ | Sensor histidine kinase PhoQ (EC 2.7.13.3) | Mutations in Pseudomonas aeruginosa PhoQ of the two-component PhoPQ regulatory system. Presence of mutation confers resistance to colistin | 90 | 99 | 0 |
CARD | P. mirabilis BB2000 | phoQ | Sensor histidine kinase PhoQ (EC 2.7.13.3) | Mutations in Pseudomonas aeruginosa PhoQ of the two-component PhoPQ regulatory system. Presence of mutation confers resistance to colistin | 98 | 98 | 1e-45 |