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Modification of therapy
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Escalation
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Change from oral to intravenous (i.v.) antibiotic treatment within the same antibacterial spectrum, change to more broad-spectrum treatment, adding an antibiotic to a combination.
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De-escalation
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Change from i.v. to oral antibiotic treatment within the same antibacterial spectrum or change to more narrow-spectrum treatment.
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Change same level
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Change to a regimen within the same antibacterial spectrum and form of administration (i.v./oral).
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Unchanged
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Regimens where first change of therapy was discontinuation of antibiotics, either during admission or after discharge.
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Time to first modification of AB regimen
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Time to first escalation/de-escalation/change within same antibacterial spectrum and dosage form (change of active substance(s), i.v. to oral switch, stopping or adding an antibiotic).
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Number of treatment regimens
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The number of treatment regimens from initiation of treatment until antibiotics prescribed at discharge
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Day of oral antibiotics
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The first day that one or more oral antibiotics were given.
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