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Table 5 Antibiotic resistance and association with antibiotic use for K. pneumoniae

From: Intra-hospital differences in antibiotic use correlate with antimicrobial resistance rate in Escherichia coli and Klebsiella pneumoniae: a retrospective observational study

  Resistance Association with antibiotic use
No. of tests/strata Proportion resistant (95% CI) Odds ratio (95% CI) p-value
Amoxicillin-clavulanic acid 648 / 115 17 (14–21) 1.07 (1.01–1.14) 0.025
Ceftriaxone 369 / 92 10 (5–18) 1.12 (0.52–2.45) 0.77
Cefepime 369 / 92 3 (1–9) 0.86 (0.59–1.25) 0.43
Piperacillin-tazobactam 369 / 92 21 (17–25) 0.84 (0.61–1.18) 0.32
Quinolones 648 / 115 6 (3–9) 1.37 (0.94–2.01) 0.10
Trimethoprim-sulfamethoxazole 648 / 115 15 (12–19) 2.02 (1.44–2.84) < 0.001
Gentamicin 369 / 92 8 (4–16) 1.82 (0.13–25.42) 0.66
Combined 3420 / 713 12 (8–16) 1.06 (0.99–1.14) 0.07
  1. Results from logistic mixed effects models. The odds ratios represent the relative change in the odds for resistance for an increase in antibiotic use by 5 DDD/100 bed-days. Strata refers to year/department combinations
  2. CI confidence interval
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