Integrated MRSA-Management (IMM) with prolonged decolonization treatment after hospital discharge is effective: a single centre, non-randomised open-label trial

Jahn, Bernhard; Wassenaar, Trudy M.; Stroh, Annemarie

doi:10.1186/s13756-016-0124-5

Antimicrobial Resistance & Infection Control

Table 3 Obtained MRSA-status at the end of the study, FAS and PPS results

From: Integrated MRSA-Management (IMM) with prolonged decolonization treatment after hospital discharge is effective: a single centre, non-randomised open-label trial

A. Full Analysis Set (FAS) of 300 subjects
Final MRSA-status n (%)	Interventional IMM-population			Inpatient control group			Chi-square test for final MRSA-status
	(N = 99)			(N = 201)			Chi-square test for final MRSA-status
	W/o skin alterations	With skin alterations	Total	W/o skin alterations	With skin alterations	Total	IMM-population vs. inpatient control group
	N = 39	N = 60	N = 99	N = 65	N = 136	N = 201	IMM-population vs. inpatient control group
MRSA-free (3 neg. swabs series)	27	19	46	8	16	24	For all patients: p < 0.001
MRSA-free (3 neg. swabs series)	(69 %)	(32 %)	(47 %)	(12 %)	(12 %)	(12 %)	For all patients: p < 0.001
Two negative swabs series	0	1	1	8	11	19	For patients without skin alterations: p < 0.001
Two negative swabs series	0	(2 %)	(1 %)	(12 %)	(8 %)	(9 %)
One negative swab series	0	0	0	15	25	40
One negative swab series	0	0	0	(23 %)	(18 %)	(20 %)
Remainder MRSA-positive	12	40	52	34	84	118	For patients with skin alterations: p < 0.001
Remainder MRSA-positive	(31 %)	(67 %)	(52 %)	(53 %)	(62 %)	(59 %)	For patients with skin alterations: p < 0.001
Total MRSA-positve	12	41	53	57	120	177
Total MRSA-positve	(31 %)	(69 %)	(53 %)	(88 %)	(88 %)	(88 %)
Chi-square test for final MRSA-status	Patients with and without skin alterations: p < 0.001			Patients with and without skin alterations: p > 0.05
B. Per Protocol Set (PPS) of 138 subjects with completed decolonization + follow-up
Final MRSA-status n (%)	Interventional IMM-population			Inpatient control group			Chi-square test for final MRSA-status
	(N = 84)			(N = 54)			Chi-square test for final MRSA-status
	W/o skin alterations	With skin alterations	Total	W/o skin alterations	With skin alterations	Total	IMM-population vs. inpatient control group
	N = 36	N = 48	N = 84	N = 14	N = 40	N = 54	IMM-population vs. inpatient control group
MRSA-free (3 neg. swabs series)	27	19	46	7	16	23	For all patients: p > 0.5
MRSA-free (3 neg. swabs series)	(75 %)	(40 %)	(55 %)	(50 %)	(40 %)	(43 %)	For all patients: p > 0.5
Two negative swabs series	0	0	0	5	6	11	For patients without skin alterations: p > 0.5
Two negative swabs series	0	0	0	(36 %)	(15 %)	(20 %)
One negative swab series	0	0	0	0	7	7
One negative swab series	0	0	0	0	(18 %)	(13 %)
Remainder MRSA-positive	9	29	38	2	11	13	For patients with skin alterations: p > 0.5
Remainder MRSA-positive	(25 %)	(60 %)	(45 %)	(14 %)	(27 %)	(24 %)	For patients with skin alterations: p > 0.5
Total MRSA-positve	9	29	38	7	24	31
Total MRSA-positve	(25 %)	(60 %)	(45 %)	(50 %)	(60 %)	(57 %)
Chi-square test for final MRSA-status	Patients with and without skin alterations: p < 0.01			Patients with and without skin alterations: p > 0.05

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