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Table 3 Obtained MRSA-status at the end of the study, FAS and PPS results

From: Integrated MRSA-Management (IMM) with prolonged decolonization treatment after hospital discharge is effective: a single centre, non-randomised open-label trial

A. Full Analysis Set (FAS) of 300 subjects
Final MRSA-status n (%) Interventional IMM-population Inpatient control group Chi-square test for final MRSA-status
(N = 99) (N = 201)
W/o skin alterations With skin alterations Total W/o skin alterations With skin alterations Total IMM-population vs. inpatient control group
N = 39 N = 60 N = 99 N = 65 N = 136 N = 201
MRSA-free (3 neg. swabs series) 27 19 46 8 16 24 For all patients: p < 0.001
(69 %) (32 %) (47 %) (12 %) (12 %) (12 %)
Two negative swabs series 0 1 1 8 11 19 For patients without skin alterations: p < 0.001
(2 %) (1 %) (12 %) (8 %) (9 %)
One negative swab series 0 0 0 15 25 40
(23 %) (18 %) (20 %)
Remainder MRSA-positive 12 40 52 34 84 118 For patients with skin alterations: p < 0.001
(31 %) (67 %) (52 %) (53 %) (62 %) (59 %)
Total MRSA-positve 12 41 53 57 120 177  
(31 %) (69 %) (53 %) (88 %) (88 %) (88 %)
Chi-square test for final MRSA-status Patients with and without skin alterations: p < 0.001 Patients with and without skin alterations: p > 0.05  
B. Per Protocol Set (PPS) of 138 subjects with completed decolonization + follow-up
Final MRSA-status n (%) Interventional IMM-population Inpatient control group Chi-square test for final MRSA-status
(N = 84) (N = 54)
W/o skin alterations With skin alterations Total W/o skin alterations With skin alterations Total IMM-population vs. inpatient control group
N = 36 N = 48 N = 84 N = 14 N = 40 N = 54
MRSA-free (3 neg. swabs series) 27 19 46 7 16 23 For all patients: p > 0.5
(75 %) (40 %) (55 %) (50 %) (40 %) (43 %)
Two negative swabs series 0 0 0 5 6 11 For patients without skin alterations: p > 0.5
(36 %) (15 %) (20 %)
One negative swab series 0 0 0 0 7 7
(18 %) (13 %)
Remainder MRSA-positive 9 29 38 2 11 13 For patients with skin alterations: p > 0.5
(25 %) (60 %) (45 %) (14 %) (27 %) (24 %)
Total MRSA-positve 9 29 38 7 24 31  
(25 %) (60 %) (45 %) (50 %) (60 %) (57 %)
Chi-square test for final MRSA-status Patients with and without skin alterations: p < 0.01 Patients with and without skin alterations: p > 0.05