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Table 2 Baseline demographics, rates of the device-associated infections, and acquisition and incidence of MDROs in patients in the MICU during the study period

From: Real-world experience of how chlorhexidine bathing affects the acquisition and incidence of vancomycin-resistant enterococci (VRE) in a medical intensive care unit with VRE endemicity: a prospective interrupted time-series study

  MICU
Pre-intervention
(26 weeks)
Intervention
(26 weeks)
p-value
No. of patients 259 242  
Age, years, median (IQR), 74 (62–81) 73 (57–81) 0.146d
Male, n (%) 155 (59.8) 140 (57.9) 0.650e
APACHE II score, median (IQR) 18 (13–23) 24 (16–32) < 0.001d
VRE rectal carriage on ICU admission, n (%) 17 (6.6) 11 (4.5) 0.326e
Receipt of surgery, n (%) 95 (36.7) 81 (33.5) 0.452e
Length of MICU stay, days, median (IQR) 13 (11–15) 13 (11–15) 0.723d
Length of hospital stay, days, median (IQR) 25 (17–49) 24 (14–45) 0.699d
In-hospital mortality, n (%) 98 (37.8) 77 (31.8) 0.158e
Device utilization ratioa
 Mechanical ventilator 0.50 0.63 < 0.001e
 Urinary catheter 0.97 0.93 0.226e
 Central venous catheter 0.64 0.63 0.927e
Device-related infectionsb
 CLA-BSI 1.25 1.28 0.983e
 CA-UTI, n (%) 1.95 2.40 0.781e
VRE acquisition rate by weekly active surveillance culturec
 Rectal VRE 20.17 9.34 < 0.001e
MDRO incidence rate by clinical culturesc
 VRE 5.11 1.60 0.006e
 MRSA 5.11 7.74 0.104e
 CRAB 11.02 11.20 0.850e
  1. CA-UTI, catheter-associated urinary tract infection; CLA-BSI, central line associated blood stream infection; ICU, intensive care unit; IQR, interquartile range; MDROs, multidrug-resistant organisms; MICU, medical intensive care unit; CRAB, carbapenem-resistant A. baumannii; MRSA, methicillin-resistant S. aureus; VAP, ventilator-associated pneumonia; VRE, vancomycin-resistant enterococci
  2. aDevice utilization ratio is calculated by dividing the number of device-days by the number of patient-days, unless otherwise stated
  3. bThe data are expressed as the total number of cases of device-associated infections per 1000 device-days, unless otherwise stated
  4. cThe data are expressed as the number of isolates per 1000 patient-days, unless otherwise stated
  5. dStudent’s t-test
  6. eChi-square test