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Table 4 Profiling of genetic mutations and MICs for LZD-resistant MTB isolates

From: Prevalence of extensively drug-resistant tuberculosis in a Chinese multidrug-resistant TB cohort after redefinition

Locus

Mutation

No. of isolates with corresponding MIC (μg/ml)

Total (%)

2

4

8

 > 8

rplC

Cys154Arg

 

5

5

2

12 (40.0)

23S rRNA

G2270C

 

1

  

1 (3.3)

 

G2270T

 

2

1

 

3 (10.0)

Wild-type

7

6

1

 

14 (46.7)

Total

7

14

7

2

30 (100.0)

  1. MIC, minimum inhibitory concentration; LZD, linezolid; MTB, Mycobacterium tuberculosis