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Table 1 Clinical features of K. pneumoniae infections

From: Clinical and microbiological characteristics of nosocomial, healthcare-associated, and community-acquired Klebsiella pneumoniae infections in Guangzhou, China

Variable Nosocomial HCA CA P-value
(n = 98) (n = 195) (n = 86) HCA versus Nosocomial CA versus Nosocomial CA versus HCA
Age (years)       
 ≤ 1 21 (21.4%) 12 (6.2%) 5 (5.8%) 0.000 0.002 0.912
 2–10 10 (10.2%) 5 (2.6%) 1 (1.2%) 0.005 0.010 0.671
 11–18 8 (8.2%) 1 (0.5%) 2 (2.3%) 0.001 0.107 0.223
 19–59 34 (34.7%) 89 (45.6%) 48 (55.8%) 0.073 0.004 0.116
  ≥ 60 25 (25.5%) 88 (45.1%) 30 (34.9%) 0.001 0.166 0.109
Sex       
 Male 56 (57.1%) 131 (67.2%) 56 (65.1%) 0.092 0.269 0.736
Infection type       
 Respiratory tract 23 (23.5%) 66 (33.9%) 18 (20.9%) 0.068 0.68 0.029
 Bloodstream 45 (45.9%) 35 (18.0%) 7 (8.1%) 0.000 0.000 0.034
 Urinary tract 9 (9.2%) 46 (23.6%) 18 (20.9%) 0.003 0.025 0.624
 Cerebra 5 (5.1%) 3 (1.5%) 0 (0.0%) 0.123 0.034 0.555
 Skin and soft tissue 3 (3.1%) 16 (8.2%) 22 (25.6%) 0.092 0.000 0.000
 Oral cavity 5 (5.1%) 3 (1.5%) 1 (1.2%) 0.123 0.217 1.000
 Other 8 (8.2%) 16 (8.2%) 11 (12.8%) 0.990 0.303 0.229
 liver 0 (0.0%) 1 (0.5%) 4 (4.7%) 1.000 0.031 0.032
 Biliary tract 0 (0.0%) 9 (4.6%) 5 (5.8%) 0.032 0.016 0.767
Underlying disease       
 Solid tumor 7 (7.1%) 20 (10.3%) 5 (5.8%) 0.385 0.716 0.264
 Diabetes mellitus 8 (8.2%) 34 (17.4%) 24 (27.9%) 0.033 0.000 0.055
 Pulmonary disease 1 (1.0%) 7 (3.6%) 5 (5.8%) 0.276 0.099 0.522
 Hematological malignancy 25 (25.5%) 23 (11.8%) 3 (3.5%) 0.003 0.000 0.027
 Brain tumor 10 (10.2%) 7 (3.6%) 2 (2.3%) 0.022 0.031 0.727
 Cerebral vascular disease 13 (13.3%) 47 (24.1%) 10 (11.6%) 0.030 0.738 0.017
 Hepatobiliary disease 7 (7.1%) 13 (6.7%) 8 (9.3%) 0.879 0.593 0.439
 Chronic kidney disease 4 (4.1%) 21 (10.8%) 7 (8.1%) 0.053 0.247 0.498
 Cardiovascular disease 4 (4.1%) 20 (10.3%) 5 (5.8%) 0.069 0.736 0.228
 Hypertension 18 (18.4%) 61 (31.3%) 17 (19.8%) 0.019 0.852 0.047
 Immunosuppression 29 (29.6%) 38 (19.5%) 6 (7.0%) 0.052 0.000 0.008
Prior antibiotic exposure       
 Any antibiotic 53 (54.1%) 115 (59.0%) 0 (0.0%) 0.424 0.000 0.000
 1st or 2nd generation cephalosporin 6 (6.1%) 7 (3.6%) 0 (0.0%)
 3rd or 4th Generation cephalosporin 10 (10.2%) 17 (8.7%) 0 (0.0%)
 β-lactam and β-lactamase inhibitor 14 (14.3%) 19 (9.7%) 0 (0.0%)
 Carbapenem 17 (17.4%) 21 (10.8%) 0 (0.0%)
 Fluoroquinolone 2 (2.0%) 5 (2.6%) 0 (0.0%)
 Aminoglycoside 2 (2.0%) 3 (1.5%) 0 (0.0%)
 Tigecycline 3 (3.1%) 3 (1.5%) 0 (0.0%)
 Glycopeptide 7 (7.1%) 12 (6.2%) 0 (0.0%)
 Metronidazole 0 (0.0%) 1 (0.5%) 0 (0.0%)
30-day crude mortality 19 (19.4%) 24 (12.3%) 4 (4.7%) 0.106 0.003 0.048
  1. Data are presented as number (%)
  2. Other included renal drainage fluid, amniotic fluid, ascites, and pleural fluid specimen
  3. Bold values suggest statistical significance
  4. not applicable