Marra AR, Schweizer ML, Edmond MB. No-touch disinfection methods to decrease multidrug-resistant organism infections: a systematic review and meta-analysis. Infect Control Hosp Epidemiol. 2018;39(1):20–31.
Dancer SJ. Controlling hospital-acquired infection: focus on the role of the environment and new technologies for decontamination. Clin Microbiol Rev. 2014;27(4):665–90.
Weber DJ, Kanamori H, Rutala WA. ‘No touch’ technologies for environmental decontamination: focus on ultraviolet devices and hydrogen peroxide systems. Curr Opin Infect Dis. 2016;29:424–31.
Tarka P, Nitsch-Osuch A. No-touch automated disinfection system for decontamination of surfaces in hospitals. Int J Environ Res Public Health. 2020;17:5131.
Cabral J, Ag R. Blue Light Disinfection in Hospital Infection Control: Advantages, Drawbacks, and Pitfalls. Antibiotics (Basel) 2019 May 7; 8(2).
Fu TY, Gent P, Kumar V. Efficacy, efficiency and safety aspects of hydrogen peroxide vapour and aerosolized hydrogen peroxide room disinfection systems. J Hosp Infect. 2012;80:199–205.
Carling PC, Huang SS. Improving healthcare environmental cleaning and disinfection: current and evolving issues. Infect Control Hosp Epidemiol. 2013;34:507–13.
Dancer SJ. Do’s and Don’ts for hospital cleaning. Curr Opin Infect Dis. 2016;29(4):415–23.
Boyce JM. Modern technologies for improving cleaning and disinfection of environmental surfaces in hospitals. Antimicrob Resist Infect Control. 2016;5:10.
Carling PC. The need for clinically relevant studies of non-touch disinfecting systems. J Hosp Infect. 2013;84:340.
Dancer SJ. Floor Wars: The Battle for ‘Clean’ surfaces. J Hosp Infect. 2013;84:339–40.
Harris AD, Lautenbach E, Perencevich E. A systematic review of quasi-experimental study designs in the fields of infection control and antibiotic resistance. Clin Infect Dis. 2005;41:77–82.
Crotty MP, Wilson MH. Enhanced terminal room disinfection and the need for multimodal collaboration. Lancet Infect Dis. 2018;18(8):814–5.
Health Quality Ontario. Portable ultraviolet light surface-disinfecting devices for prevention of hospital-acquired infections: a health technology assessment. Ont Health Technol Assess Ser 2018; 18(1):1–73. eCollection 2018.
Hooker EA. Increased time spent on terminal cleaning of patient rooms may not improve disinfection of high-touch surfaces. Infect Control Hosp Epidemiol. 2019;40(9):1086.
Murphy P, Kang L, Fleming M, Atkinson C, Pryor R, Cooper K, Godbout E, Stevens MP, Doll M, Bearman G. Effect of ultraviolet-C light disinfection at terminal patient discharge on hospital-acquired infections in bone marrow transplant and oncology units. Am J Infect Control 2020; in press.
Morikane K, Suzuki S, Yoshioka J, Yakuwa J, Nakane M, Nemoto K. Clinical and microbiological effect of pulsed xenon ultraviolet disinfection to reduce multidrug-resistant organisms in the intensive care unit in a Japanese hospital: a before–after study. BMC Infect Dis. 2020;20(1):82.
Attia F, Whitener C, Mincemoyer S, Houck J, Julian K. The effect of pulsed xenon ultraviolet light disinfection on healthcare-associated Clostridioides difficile rates in a tertiary care hospital. Am J Infect Control 2020; in press.
García-Arenzana N, Redondo-Bravo L, Espinel-Ruiz MA, Borrego-Prieto P, Ruiz-Carrascoso G, Quintas-Viqueira A, Sanchez-Calles A, Robustillo-Rodela A. Carbapenem-resistant enterobacteriaceae outbreak in a medical ward in Spain: epidemiology, control strategy, and importance of environmental disinfection. Microb Drug Resist. 2020;26(1):54–9.
Frakking FNJ, Bril WS, Sinnige JC, Klooster JEV, de Jong BAW, van Hannen EJ, Tersmette M. Recommendations for the successful control of a large outbreak of vancomycin-resistant Enterococcus faecium in a non-endemic hospital setting. J Hosp Infect. 2018;100(4):e216–25.
Rutala WA, Kanamori H, Gergen MF, Knelson LP, Sickbert-Bennett EE, Chen LF, Anderson DJ, Sexton DJ, Weber DJ, The CDC Prevention Epicenters Program. Enhanced disinfection leads to reduction of microbial contamination and a decrease in patient colonization and infection. Infect Control Hosp Epidemiol. 2018;39(9):1118–21.
Raggi R, Archulet K, Haag CW, Tang W. Clinical, operational, and financial impact of an ultraviolet-C terminal disinfection intervention at a community hospital. Am J Infect Control. 2018;46(11):1224–9.
Brite J, McMillen T, Robilotti E, Sun J, Chow HY, Stell F, Seo SK, McKenna D, Eagan J, Montecalvo M, Chen D, Sepkowitz K, Kamboj M. Effectiveness of ultraviolet disinfection in reducing hospital-acquired Clostridium difficile and vancomycin-resistant Enterococcus on a bone marrow transplant unit. Infect Control Hosp Epidemiol. 2018;39(11):1301–6.
Anderson DJ, Moehring RW, Weber DJ, Lewis SS, Chen LF, Schwab JC, Becherer P, Blocker M, Triplett PF, Knelson LP, Lokhnygina Y, Rutala WA, Sexton DJ, CDC Prevention Epicenters Program. Effectiveness of targeted enhanced terminal room disinfection on hospital-wide acquisition and infection with multidrug-resistant organisms and Clostridium difficile: a secondary analysis of a multicentre cluster randomised controlled trial with crossover design (BETR Disinfection). Lancet Infect Dis. 2018;18(8):845–53.
Sampathkumar P, Folkert C, Barth JE, Nation L, Benz M, Hesse A, Mielke Ms CL, Zaveleta KW. A trial of pulsed xenon ultraviolet disinfection to reduce Clostridioides difficile infection. Am J Infect Control. 2019;47(4):406–8.
Ethington T, Newsome S, Waugh J, Lee LD. Cleaning the air with ultraviolet germicidal irradiation lessened contact infections in a long-term acute care hospital. Am J Infect Control. 2018;46(5):482–6.
Kane DW, Finley C, Brown D. UV-C light and infection rate in a long term care ventilator unit. Can J Infect Control. 2018;33:44–8.
Fleming M, Patrick A, Gryskevicz M, Masroor N, Hassmer L, Shimp K, Cooper K, Doll M, Stevens M, Bearman G. Deployment of a touchless ultraviolet light robot for terminal room disinfection: The importance of audit and feedback. Am J Infect Control. 2018;46(2):241–3.
Kovach CR, Taneli Y, Neiman T, Dyer EM, Arzaga AJ, Kelber ST. Evaluation of an ultraviolet room disinfection protocol to decrease nursing home microbial burden, infection and hospitalization rates. BMC Infect Dis. 2017;17(1):186.
Anderson DJ, Chen LF, Weber DJ, Moehring RW, Lewis SS, Triplett PF, Blocker M, Becherer P, Schwab JC, Knelson LP, Lokhnygina Y, Rutala WA, Kanamori H, Gergen MF, Sexton DJ, CDC Prevention Epicenters Program. Enhanced terminal room disinfection and acquisition and infection caused by multidrug-resistant organisms and Clostridium difficile (the Benefits of Enhanced Terminal Room Disinfection study): a cluster-randomized, multicentre crossover study. Lancet. 2017;389:805–14.
Pegues DA, Han J, Gilmar C, McDonnell B, Gaynes S. Impact of ultraviolet germicidal irradiation for no-touch terminal room disinfection on Clostridium difficile infection incidence among hematology–oncology patients. Infect Control Hosp Epidemiol. 2017;38:39–44.
Yui S, Ali S, Muzslay M, Jeanes A, Wilson APR. Identification of Clostridium difficile reservoirs in the patient environment and efficacy of aerial hydrogen peroxide decontamination. Infect Control Hosp Epidemiol. 2017;38(12):1487–92.
Robustillo-Rodela A, Pérez-Blanco V, Espinel Ruiz MA, Ruiz Carrascoso G, Figueira Iglesias JC, Abad MD. Successful control of 2 simultaneous outbreaks of OXA-48 carbapenemase-producing Enterobacteriaceae and multidrug-resistant Acinetobacter baumannii in an intensive care unit. Am J Infect Control. 2017;45(12):1356–62.
Green C, Pamplin JC, Chafin KN, Murray CK, Yun HC. Pulsed-xenon ultraviolet light disinfection in a burn unit: impact on environmental bioburden, multidrug-resistant organism acquisition and healthcare associated infections. Burns. 2017;43(2):388–96.
Vianna PG, Dale CR Jr, Simmons S, Stibich M, Licitra CM. Impact of pulsed xenon ultraviolet light on hospital-acquired infection rates in a community hospital. Am J Infect Control. 2016;44(3):299–303.
Catalanotti A, Abbe D, Simmons S, Stibich M. Influence of pulsed-xenon ultraviolet light-based environmental disinfection on surgical site infections. Am J Infect Control. 2016;44(6):e99–101.
McCord J, Prewitt M, Dyakova E, Mookerjee S, Otter JA. Reduction in Clostridium difficile infection associated with the introduction of hydrogen peroxide vapour automated room disinfection. J Hosp Infect. 2016;94(2):185–7.
Horn K, Otter JA. Hydrogen peroxide vapor room disinfection and hand hygiene improvements reduce Clostridium difficile infection, methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci and extended-spectrum b-lactamase. Am J Infect Control. 2015;43:1354–6.
Napolitano NA, Mahapatra T, Tang W. The effectiveness of UV-C radiation for facility-wide environmental disinfection to reduce health care-acquired infections. Am J Infect Control. 2015;43(12):1342–6.
Nagaraja A, Visintainer P, Haas JP, Menz J, Wormser GP, Montecalvo MA. Clostridium difficile infections before and during use of ultraviolet disinfection. Am J Infect Control. 2015;43(9):940–5.
Miller R, Simmons S, Dale C, Stachowiak J, Stibich M. Utilization and impact of a pulsed-xenon ultraviolet room disinfection system and multidisciplinary care team on Clostridium difficile in a long-term acute care facility. Am J Infect Control. 2015;43:1350–3.
Mitchell BG, Digney W, Locket P, Dancer SJ. Controlling methicillin-resistant Staphylococcus aureus (MRSA) in a hospital and the role of hydrogen peroxide decontamination: an interrupted time series analysis. BMJ Open. 2014;4(4):e004522.
Haas JP, Menz J, Dusza S, Montecalvo MA. Implementation and impact of ultraviolet environmental disinfection in an acute care setting. Am J Infect Control. 2014;42:586–90.
Best EL, Parnell P, Thirkell G, Verity P, Copland M, Else P, Denton M, Hobson RP, Wilcox MH. Effectiveness of deep cleaning followed by hydrogen peroxide decontamination during high Clostridium difficile infection incidence. J Hosp Infect. 2014;87(1):25–33.
Alfandari S, Gois J, Delannoy PY, Georges H, Boussekey N, Chiche A, Meybeck A, Patoz P, Blondiaux N, Senneville E, Melliez H, Leroy O. Management and control of a carbapenem-resistant Acinetobacter baumannii outbreak in an intensive care unit. Med Mal Infect. 2014;44(5):229–31.
Landelle C, Legrand P, Lesprit P, Cizeau F, Ducellier D, Gouot C, Bréhaut P, Soing-Altrach S, Girou E, Brun-Buisson C. Protracted outbreak of multidrug-resistant Acinetobacter baumannii after intercontinental transfer of colonized patients. Infect Control Hosp Epidemiol. 2013;34(2):119–24.
Passaretti CL, Otter JA, Reich NG, Myers J, Shepard J, Ross T, Carroll KC, Lipsett P, Perl TM. An evaluation of environmental decontamination with hydrogen peroxide vapor for reducing the risk of patient acquisition of multidrug-resistant organisms. Clin Infect Dis. 2012;56:27–35.
Levin J, Riley LS, Parrish C, English D, Ahn S. The effect of portable pulsed xenon ultraviolet light after terminal cleaning on hospital-associated Clostridium difficile infection in a community hospital. Am J Infect Control. 2013;41:746–8.
Manian FA, Griesnauer S, Bryant A. Implementation of hospital wide enhanced terminal cleaning of targeted patient rooms and its impact on endemic Clostridium difficile infection rates. Am J Infect Control. 2013;41:537–41.
Sitzlar B, Deshpande A, Fertelli D, Kundrapu S, Sethi AK, Donskey CJ. An environmental disinfection odyssey: evaluation of sequential interventions to improve disinfection of Clostridium difficile isolation rooms. Infect Control Hosp Epidemiol. 2013;34(5):459–65.
Barbut F, Yezli S, Mimoun M, Pham J, Chaouat M, Otter JA. Reducing the spread of Acinetobacter baumannii and methicillin-resistant Staphylococcus aureus on a burns unit through the intervention of an infection control bundle. Burns. 2013;39(3):395–403.
Chmielarczyk A, Higgins PG, Wojkowska-Mach J, Synowiec E, Zander E, Romaniszyn D, Gosiewski T, Seifert H, Heczko P, Bulanda M. Control of an outbreak of Acinetobacter baumannii infections using vaporized hydrogen peroxide. J Hosp Infect. 2012;81(4):239–45.
Cooper T, O’Leary M, Yezli S, Otter JA. Impact of environmental decontamination using hydrogen peroxide vapour on the incidence of Clostridium difficile infection in one hospital Trust. J Hosp Infect. 2011;78:238–40.
Otter JA, Yezli S, Schouten MA, van Zanten AR, Houmes-Zielman G, Nohlmans-Paulssen MK. Hydrogen peroxide vapour decontamination of an intensive care unit to remove environmental reservoirs of multidrug-resistant gram-negative rods during an outbreak. Am J Infect Control. 2010;38(9):754–6.
Ray A, Perez F, Beltramini AM, Jakubowycz M, Dimick P, Jacobs MR, Roman K, Bonomo RA, Salata RA. Use of vaporized hydrogen peroxide decontamination during an outbreak of multidrug-resistant Acinetobacter baumannii infection at a long-term acute care hospital. Infect Control Hosp Epidemiol. 2010;31(12):1236–41.
Dryden M, Parnaby R, Dailly S, Lewis T, Davis-Blues K, Otter JA, Kearns AM. Hydrogen peroxide vapour decontamination in the control of a polyclonal meticillin-resistant Staphylococcus aureus outbreak on a surgical ward. J Hosp Infect. 2008;68(2):190–2.
Boyce JM, Havill NL, Otter JA, McDonald LC, Adams NM, Cooper T, Thompson A, Wiggs L, Killgore G, Tauman A, Noble-Wang J. Impact of hydrogen peroxide vapor room decontamination on Clostridium difficile environmental contamination and transmission in a healthcare setting. Infect Control Hosp Epidemiol. 2008;29:723–9.
Bates CJ, Pearse R. Use of hydrogen peroxide vapour for environmental control during a Serratia outbreak in a neonatal intensive care unit. J Hosp Infect. 2005;61(4):364–6.
De Kraker M, Harbarth S, Dancer SJ. Shining a light on ultraviolet-C disinfection: no golden promises for infection prevention. Am J Infect Control. 2018;46(12):1422–3.
Hayden MK, Bonten MJ, Blom DW, Lyle EA, van de Vijver DA, Weinstein RA. Reduction in acquisition of vancomycin-resistant Enterococcus after enforcement of routine environmental cleaning measures. Clin Infect Dis. 2006;42:1552–60.
Dancer SJ. Hospital cleaning in the 21st century. Eur J Clin Microbiol Infect Dis. 2011;30:1473–81.
Leas BF, Sullivan N, Han JH, Pegues DA, Kaczmarek JL, Umscheid CA. Environmental cleaning for the prevention of healthcare-associated infections. Agency for Healthcare Research and Quality, Rockville (MD) (2015) Report No.: 15-EHC020-EF. AHRQ Comparative Effectiveness Technical Briefs.
Chen LF, Knelson LP, Gergen MF, Better OM, Nicholson BP, Woods CW, Rutala WA, Weber DJ, Sexton DJ, Anderson DJ. A prospective study of transmission of Multidrug-Resistant Organisms (MDROs) between environmental sites and hospitalized patients-the TransFER study. Infect Control Hosp Epidemiol. 2019;40(1):47–52.
Anderson DJ, Knelson LP, Moehring RW, Lewis SS, Weber DJ, Chen LF, Triplett PF, Blocker M, Cooney RM, Schwab JC, Lokhnygina Y, Rutala WA, Sexton DJ, CDC Prevention Epicenters Program. Implementation Lessons Learned From the Benefits of Enhanced Terminal Room (BETR) disinfection study: process and perceptions of enhanced disinfection with ultraviolet disinfection devices. Infect Control Hosp Epidemiol. 2018;39(2):157–63.
Knelson LP, Ramadanovic GK, Chen LF, Moehring RW, Lewis SS, Rutala WA, Weber DJ, Sexton DJ, Anderson DJ, CDC Prevention EpiCenters Program. Self-monitoring by Environmental Services may not accurately measure thoroughness of hospital room cleaning. Infect Control Hosp Epidemiol. 2017;38(11):1371–3.
Smith R. The Trouble with Medical Journals. Royal Society of Medicine Press, 2006. ISBN: 978-1-85315-673-1.
Doan L, Forrest H, Fakis A, Craig J, Claxton L, Khare M. Clinical and cost effectiveness of eight disinfection methods for terminal disinfection of hospital isolation rooms contaminated with Clostridium difficile 027. J Hosp Infect. 2012;82(2):114–21.
Beal A, Mahida N, Staniforth K, Vaughan N, Clarke M, Boswell T. First UK trial of Xenex PX-UV, an automated ultraviolet room decontamination device in a clinical haematology and bone marrow transplantation unit. J Hosp Infect. 2016;93:164–8.
Hosein I, Madeloso R, Nagaratnam W, Villamaria F, Stock E, Jinadatha C. Evaluation of a pulsed xenon ultraviolet light device for isolation room disinfection in a United Kingdom hospital. Am J Infect Control. 2016;44:157–61.
Jinadatha C, Quezada R, Huber T, Williams J, Zeber J, Copeland L. Evaluation of a pulsed-xenon ultraviolet room disinfection device for impact on contamination levels of methicillin-resistant Staphylococcus aureus. BMC Infect Dis. 2014;14:187.
Nerandzic M, Cadnum J, Pultz M, Donskey C. Evaluation of an automated ultraviolet radiation device for decontamination of Clostridium difficile and other healthcare-associated pathogens in hospital rooms. BMC Infect Dis. 2010;10:197.
Penno K, Jandarov RA, Sopirala MM. Effect of automated ultraviolet C-emitting device on decontamination of hospital rooms with and without real-time observation of terminal room disinfection. Am J Infect Control. 2018;45:1208–13.
Dunn AN, Vaisberg P, Fraser TG, Donskey CJ, Deshpande A. Perceptions of patients, health care workers, and environmental services staff regarding ultraviolet light room decontamination devices. Am J Infect Control. 2019;47(11):1290–3.
Barbut F. How to eradicate Clostridium difficile from the environment. J Hosp Infect. 2015;89(4):287–95.
Hardy KJ, Gossain S, Henderson N, Drugan C, Oppenheim BA, Gao F, Hawkey PM. Rapid recontamination with MRSA of the environment of an intensive care unit after decontamination with hydrogen peroxide vapour. J Hosp Infect. 2007;66:360–8.
Cadnum JL, Tomas ME, Sankar T, Jencson A, Mathew JI, Kundrapu S, et al. Effect of variation in test methods on performance of ultraviolet-C radiation room decontamination. Infect Control Hosp Epidemiol. 2016;37:555–60.
Wang Z, Kowal SF, Carslaw N, Kahan TF. Photolysis driven indoor air chemistry following cleaning of hospital wards. Indoor Air 2020; in press.
European Commission. Assessment of the antibiotic resistance effects of biocides. European Commission, Brussels, Belgium (2009). https://ec.europa.eu/health/ph_risk/committees/04_scenihr/docs/scenihr_o_021.pdf.
Sattar SA. Promises and pitfalls of recent advances in chemical means of preventing the spread of nosocomial infections by environmental surfaces. Am J Infect Control. 2010;38(5 Suppl 1):S34-40.
Kampf G. Challenging biocide tolerance with antiseptic stewardship. J Hosp Infect. 2018;100:e37–9.
Mora M, Mahnert A, Koskinen K, Pausan MR, Oberauner-Wappis L, Krause R, Perras AK, Gorkiewicz G, Berg G, Moissl-Eichinger C. Microorganisms in confined habitats: microbial monitoring and control of intensive care units, operating rooms, cleanrooms and the international space station. Front Microbiol. 2016;7:1573 (eCollection 2016).
Velasquez S, Griffiths W, Dietz L, Horve P, Nunez S, Hu J, Shen J, Fretz M, Bi C, Xu Y, Van Den Wymelenberg KG, Hartmann EM, Ishaq SL. From one species to another: a review on the interaction between chemistry and microbiology in relation to cleaning in the built environment. Indoor Air. 2019;29(6):880–94.
de Bruijn FJ. Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria, I&II. New York : Wiley; 2016. https://0-doi-org.brum.beds.ac.uk/10.1002/9781119004813.
Goldman RP, Travisano M. Experimental evolution of ultraviolet radiation resistance in Escherichia coli. Evolution. 2011;65:3486–98.
Stewart M, Bogusz A, Hunter J, Devanny I, Yip B, Reid D, Robertson C, Dancer SJ. Microbiological effect of cleaning near-patient sites with electrolysed water. Infect Control Hosp Epidemiol. 2014;35(12):1505–10.
Kramer A, Schwebke I, Kampf G. How long do nosocomial pathogens persist on inanimate surfaces? A systematic review. BMC Infect Dis. 2006;6:130.
Vickery K, Deva A, Jacombs A, Allan J, Valente P, Gosbell I. Presence of biofilm containing viable multiresistant organisms despite terminal cleaning on clinical surfaces in an intensive care unit. J Hosp Infect. 2012;80:52–5.
Fux CA, Costerton JW, Stewart PS, Stoodley P. Survival strategies of infectious biofilms. Trends Microbiol. 2005;13:34–40.
Curran ET, Wilkinson M, Bradley T. Chemical disinfectants: controversies regarding their use in low risk healthcare environments (part 1). J Infect Prevent. 2019;20(2):76–82.
Donskey CJ. Decontamination devices in health care facilities: practical issues and emerging applications. Am J Infect Control. 2019;47:A23–8.
Dancer SJ. Infection control; evidence-based common sense. Infect Dis Health. 2016;21(4):147–53.
Dancer SJ, Kramer A. Four steps to clean hospitals: look; plan, clean; and dry. J Hosp Infect. 2019;103(1):e1–8.