Does vancomycin resistance increase mortality in Enterococcus faecium bacteraemia after orthotopic liver transplantation? A retrospective study

Table 4 Factors associated with unfavourable outcomes 30 days after Enterococcus faecium bacteraemia (logistic regression)

			Univariate			Multivariate
Variables	Patients with favourable outcome n = 95	Patients with unfavourable outcome n = 80	OR	95% CI	p	OR	95% CI	p
Definitive infectious focus elimination
Yes	28 (29.5)	17 (21.2)	1.55	0.77–3.10	0.217	1.92	0.79–4.66	0.150
No	67 (70.5)	63 (78.8)
Start of adequate AB Therapy within < 48 h post-BSI onset
Yes	48 (50.5)	54 (67.5)	2.03	1.10–3.77	0.0241	1.62	0.73–3.60	0.238
No	47 (49.5)	26 (32.5)
Mean SOFA_Non-GCS (day-7 until day-1 before BSI onset)	4.8 ± 3.8	10.8 ± 4.2	1.39	1.26–1.53	< 0.001	1.2%	1.10–1.41	< 0.001
ICU stay between day-7 and BSI onset [days]	3.7 ± 3.5	7.4 ± 1.8	1.55	1.34–1.78	< 0.001	1.24	1.03–1.49	0.023
Bacteraemia
VRE	19 (48.7)	20 (51.3)	1.33	0.65–2.72	0.429	1.13	0.46–2.76	0.795
VSE	76 (55.9)	60 (44.1)

Favourable outcome was defined as stay at home, on the ward or in a rehabilitation centre; unfavourable outcome was defined as death or ongoing need for ICU treatment.
Data are presented as n (%) or mean ± standard deviation.
*n = 175 (2 missing)
Abbreviations: OR odds ratio, CI confidence interval, AB antibiotic therapy, BSI bloodstream infection, SOFA sequential organ failure assessment, GCS Glasgow coma scale, VRE vancomycin-resistant Enterococcus faecium, VSE vancomycin-susceptible Enterococcus faecium

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