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Table 1 Baseline and Procedural Characteristics, by Surgical Antimicrobial Prophylaxis Administration (Before Incision / After Cord Clamping)

From: Antimicrobial prophylaxis administration after umbilical cord clamping in cesarean section and the risk of surgical site infection: a cohort study with 55,901 patients

 

Before incision

After cord clamping

p

n

26,405

29,496

 

Age (%)

  

0.043

 < 30 years

7891 (29.9)

8902 (30.2)

 

 30–40 years

16,631 (63.0)

18,346 (62.2)

 

 > 40 years

1883 (7.1)

2248 (7.6)

 

BMI in kg/m2, median [IQR])a

28.0 [25.2, 31.6]

27.3 [24.2, 30.9]

< 0.001

SAP agent (%)

  

< 0.001

 Amoxicillin + Clavulanate

3601 (13.6)

1770 (6.0)

 

 Cefazolin

9081 (34.4)

9073 (30.8)

 

 Ceftriaxone

782 (3.0)

5117 (17.3)

 

 Cefuroxime

12,941 (49.0)

13,536 (45.9)

 

Minutes between SAP administration and incision

−15 [−25, −9]

10 [5, 15]

< 0.001

Elective surgery = yes (%)

13,458 (51.0)

14,820 (50.2)

0.089

ASA Score (%)

  

< 0.001

 ASA 1

4427 (16.8)

6862 (23.3)

 

 ASA 2

20,229 (76.6)

20,648 (70.0)

 

 ASA 3/4/5

1401 (5.3)

1514 (5.1)

 

 NA

348 (1.3)

472 (1.6)

 

Contaminated wound = yes (%)

5724 (21.7)

6440 (21.8)

0.663

Procedure duration in minutes (median [IQR])b

38 [29, 49]

37 [29, 48]

< 0.001

Hospital bed size (%)

  

< 0.001

 < 200

12,328 (46.7)

17,588 (59.6)

 

 200–499

11,497 (43.5)

5757 (19.5)

 

 500+

2580 (9.8)

6151 (20.9)

 

Procedure after January 1, 2014 = yes (%)

18,081 (68.5)

9612 (32.6)

< 0.001

  1. Abbreviations
  2. ASA American Society of Anesthesiologists
  3. BMI Body mass index
  4. IQR Interquartile range
  5. SAP Surgical antimicrobial prophylaxis
  6. aBMI NA: Before =15′510 (58.7%); After = 18′052 (61.2%)
  7. bDuration NA: Before =144 (0.5%); After = 94 (0.3%)