Organism/antibiotic | No. of isolates | MIC50 | MIC90 | MIC range | CLSIa | EUCAST | ||||
---|---|---|---|---|---|---|---|---|---|---|
S% | I% | R% | S% | I% | R% | |||||
Escherichia coli | ||||||||||
Ceftaroline | 21903 | 0.12 | 256 | 0.015–256 | 66.5 | 2.6 | 30.9 | 66.5 | 0 | 33.5 |
Ceftazidime–avibactam | 21903 | 0.12 | 0.25 | 0.015–256 | 99.8 | 0 | 0.2 | 99.8 | 0 | 0.2 |
Ceftazidime | 21903 | 0.25 | 32 | 0.015–256 | 79.2 | 3.0 | 17.8 | 74.0 | 5.1 | 20.8 |
Cefepime | 21903 | 0.12 | 32 | 0.12–32 | 76.2 | 4.7 | 19.1 | 74.6 | 3.6 | 21.8 |
Pip-taz | 21903 | 2 | 16 | 0.25–256 | 90.3 | 4.6 | 5.1 | 84.8 | 5.4 | 9.8 |
Doripenem | 21903 | 0.03 | 0.06 | 0.008–16 | 99.6 | 0.1 | 0.3 | 99.6 | 0.1 | 0.3 |
Imipenem | 21903 | 0.25 | 0.25 | 0.03–16 | 99.1 | 0.4 | 0.5 | 99.5 | 0.4 | 0.2 |
Meropenem | 21903 | 0.03 | 0.06 | 0.004–16 | 99.5 | 0.1 | 0.4 | 99.6 | 0.2 | 0.2 |
Levofloxacin | 21903 | 0.25 | 16 | 0.004–16 | 62.3 | 1.7 | 36.0 | 58.8 | 2.8 | 38.4 |
Tigecycline | 21903 | 0.25 | 0.5 | 0.015–16 | 99.8 | 0.2 | 0 | 99.0 | 0.8 | 0.2 |
Amikacin | 21903 | 2 | 8 | 0.25–64 | 98.2 | 0.9 | 0.9 | 94.5 | 3.7 | 1.8 |
Colistin | 13964 | 0.5 | 1 | 0.06–16 | NA | NA | NA | 99.5 | 0 | 0.5 |
Aztreonam | 21903 | 0.12 | 64 | 0.015–256 | 76.0 | 3.1 | 20.9 | 72.3 | 3.7 | 24.0 |
Klebsiella pneumoniae | ||||||||||
Ceftaroline | 18114 | 0.25 | 256 | 0.015–256 | 57.5 | 2.0 | 40.5 | 57.5 | 0 | 42.5 |
Ceftazidime–avibactam | 18114 | 0.12 | 1 | 0.015–256 | 98.8 | 0 | 1.2 | 98.8 | 0 | 1.2 |
Ceftazidime | 18114 | 0.25 | 128 | 0.015–256 | 64.3 | 1.9 | 33.8 | 61.6 | 2.7 | 35.7 |
Cefepime | 18114 | 0.12 | 32 | 0.12–32 | 65.1 | 6.0 | 28.9 | 63.7 | 3.2 | 33.1 |
Pip/taz | 18114 | 4 | 256 | 0.25–256 | 73.0 | 7.8 | 19.2 | 64.4 | 8.6 | 27.0 |
Doripenem | 18114 | 0.06 | 0.5 | 0.008–16 | 91.6 | 1.0 | 7.4 | 91.6 | 1.0 | 7.4 |
Imipenem | 18114 | 0.25 | 1 | 0.03–16 | 90.3 | 1.9 | 7.8 | 92.2 | 2.4 | 5.5 |
Meropenem | 18114 | 0.06 | 0.5 | 0.004–16 | 91.1 | 1.1 | 7.9 | 92.1 | 2.0 | 5.9 |
Levofloxacin | 18114 | 0.12 | 8 | 0.004–16 | 73.2 | 3.1 | 23.7 | 61.8 | 9.1 | 29.1 |
Tigecycline | 18114 | 0.5 | 2 | 0.015–16 | 96.4 | 3.1 | 0.5 | 88.2 | 8.2 | 3.6 |
Amikacin | 18114 | 1 | 8 | 0.25–64 | 93.6 | 3.0 | 3.4 | 91.0 | 2.6 | 6.4 |
Colistin | 12884 | 0.5 | 1 | 0.06–16 | NA | NA | NA | 96.3 | 0 | 3.7 |
Aztreonam | 18114 | 0.12 | 256 | 0.015–256 | 64.2 | 1.0 | 34.8 | 62.4 | 1.8 | 35.8 |
Enterobacter cloacae | ||||||||||
Ceftaroline | 4330 | 0.5 | 256 | 0.015–256 | 60.0 | 3.1 | 37.0 | 60.0 | 0.0 | 40.1 |
Ceftazidime–avibactam | 4330 | 0.25 | 1 | 0.015–256 | 97.8 | 0.0 | 2.2 | 97.8 | 0.0 | 2.2 |
Ceftazidime | 4330 | 0.5 | 128 | 0.015–256 | 67.3 | 1.4 | 31.3 | 64.0 | 3.3 | 32.7 |
Cefepime | 4330 | 0.12 | 32 | 0.12–32 | 78.5 | 8.8 | 12.7 | 73.3 | 10.8 | 15.9 |
Pip-taz | 4330 | 4 | 256 | 0.25–256 | 75.3 | 8.0 | 16.7 | 69.9 | 5.4 | 24.7 |
Doripenem | 4330 | 0.06 | 0.25 | 0.008–16 | 96.8 | 0.4 | 2.9 | 96.8 | 0.4 | 2.9 |
Imipenem | 4330 | 0.5 | 1 | 0.03–16 | 93.1 | 3.5 | 3.4 | 96.6 | 2.0 | 1.5 |
Meropenem | 4330 | 0.06 | 0.12 | 0.004–16 | 96.8 | 0.6 | 2.6 | 97.4 | 1.3 | 1.3 |
Levofloxacin | 4330 | 0.06 | 4 | 0.004–16 | 88.8 | 2.8 | 8.4 | 80.8 | 5.7 | 13.5 |
Tigecycline | 4330 | 0.5 | 1 | 0.015–16 | 96.3 | 3.2 | 0.5 | 90.1 | 6.2 | 3.7 |
Amikacin | 4330 | 2 | 4 | 0.25–64 | 97.6 | 0.9 | 1.6 | 96.0 | 1.6 | 2.4 |
Colistin | 2889 | 0.5 | 1 | 0.12–16 | NA | NA | NA | 93.7 | 0.0 | 6.3 |
Aztreonam | 4330 | 0.12 | 64 | 0.015–256 | 68.2 | 1.4 | 30.4 | 65.8 | 2.4 | 31.8 |
Citrobacter freundii | ||||||||||
Ceftaroline | 2327 | 0.25 | 128 | 0.015–256 | 61.9 | 2.1 | 36.0 | 61.9 | 0 | 38.1 |
Ceftazidime–avibactam | 2327 | 0.12 | 0.5 | 0.015–256 | 98.5 | 0 | 1.5 | 98.5 | 0 | 1.5 |
Ceftazidime | 2327 | 0.5 | 128 | 0.015–256 | 68.0 | 1.9 | 30.1 | 64.3 | 3.8 | 32.0 |
Cefepime | 2327 | 0.12 | 4 | 0.12–32 | 89.8 | 3.6 | 6.7 | 84.4 | 7.3 | 8.4 |
Pip-taz | 2327 | 4 | 128 | 0.25–256 | 77.1 | 12.0 | 11.0 | 70.5 | 6.6 | 23.0 |
Doripenem | 2327 | 0.06 | 0.12 | 0.008–16 | 97.9 | 0.3 | 1.8 | 97.9 | 0.3 | 1.8 |
Imipenem | 2327 | 0.5 | 2 | 0.03–16 | 88.9 | 8.5 | 2.6 | 97.4 | 2.1 | 0.5 |
Meropenem | 2327 | 0.03 | 0.06 | 0.004–16 | 97.7 | 0.5 | 1.8 | 98.2 | 1.2 | 0.6 |
Levofloxacin | 2327 | 0.12 | 4 | 0.008–16 | 87.0 | 4.0 | 9.0 | 76.5 | 6.2 | 17.3 |
Tigecycline | 2327 | 0.5 | 1 | 0.015–8 | 98.9 | 1.1 | 0 | 94.9 | 4.0 | 1.1 |
Amikacin | 2327 | 2 | 4 | 0.25–64 | 98.4 | 0.4 | 1.2 | 97.1 | 1.3 | 1.6 |
Colistin | 1593 | 0.5 | 1 | 0.06–16 | NA | NA | NA | 99.6 | 0 | 0.4 |
Aztreonam | 2327 | 0.25 | 64 | 0.015–256 | 69.2 | 2.4 | 28.4 | 66.2 | 3.1 | 30.8 |
Proteus mirabilis | ||||||||||
Ceftaroline | 3950 | 0.12 | 128 | 0.015–256 | 79.4 | 2.0 | 18.6 | 79.4 | 0 | 20.6 |
Ceftazidime–avibactam | 3950 | 0.03 | 0.06 | 0.015–256 | 99.7 | 0 | 0.3 | 99.7 | 0 | 0.3 |
Ceftazidime | 3950 | 0.06 | 1 | 0.015–256 | 95.2 | 1.7 | 3.1 | 91.1 | 4.1 | 4.8 |
Cefepime | 3950 | 0.12 | 8 | 0.12–32 | 88.2 | 3.4 | 8.5 | 86.9 | 2.9 | 10.3 |
Pip-taz | 3950 | 0.5 | 1 | 0.25–256 | 98.5 | 0.9 | 0.6 | 97.7 | 0.8 | 1.5 |
Doripenem | 3950 | 0.25 | 0.5 | 0.008–16 | 98.4 | 1.0 | 0.6 | 98.4 | 1.0 | 0.6 |
Imipenem | 3950 | 2 | 4 | 0.03–16 | 25.8 | 45.9 | 28.3 | 71.7 | 27.7 | 0.6 |
Meropenem | 3950 | 0.06 | 0.12 | 0.004–16 | 99.6 | 0.2 | 0.3 | 99.8 | 0.2 | 0.1 |
Levofloxacin | 3950 | 0.12 | 8 | 0.015–16 | 76.6 | 5.5 | 17.9 | 64.9 | 4.5 | 30.6 |
Tigecycline | 3950 | 2 | 8 | 0.03–16 | 52.2 | 37.3 | 10.5 | 20.9 | 31.3 | 47.8 |
Amikacin | 3950 | 4 | 8 | 0.25–64 | 95.6 | 1.1 | 3.4 | 91.5 | 4.1 | 4.4 |
Colistin | 2412 | 16 | 16 | 0.25–16 | NA | NA | NA | 0.5 | 0 | 99.5 |
Aztreonam | 3950 | 0.015 | 0.5 | 0.015–256 | 95.9 | 0.8 | 3.3 | 93.1 | 2.9 | 4.1 |
Pseudomonas aeruginosa | ||||||||||
Ceftaroline | 16014 | 16 | 256 | 0.015–256 | NA | NA | NA | NA | NA | NA |
Ceftazidime–avibactam | 16014 | 2 | 8 | 0.015–256 | 91.9 | 0 | 8.1 | 91.9 | 0 | 8.1 |
Ceftazidime | 16014 | 4 | 64 | 0.06–256 | 76.7 | 4.6 | 18.8 | 76.7 | 0 | 23.4 |
Cefepime | 16014 | 4 | 32 | 0.12–32 | 78.4 | 11.2 | 10.5 | 78.4 | 0 | 21.6 |
Pip-taz | 16014 | 8 | 256 | 0.25–256 | 68.9 | 13.8 | 17.3 | 68.9 | 0 | 31.2 |
Doripenem | 16013 | 0.5 | 8 | 0.008–16 | 74.3 | 7.6 | 18.2 | 67 | 7.2 | 25.8 |
Imipenem | 16014 | 2 | 16 | 0.03–16 | 63.4 | 8.2 | 28.4 | 71.6 | 4.5 | 23.9 |
Meropenem | 16014 | 0.5 | 16 | 0.008–16 | 72.5 | 6.0 | 21.5 | 72.5 | 11.9 | 15.6 |
Levofloxacin | 16014 | 1 | 8 | 0.004–16 | 70.4 | 6.8 | 22.9 | 61.7 | 0 | 38.3 |
Amikacin | 16014 | 4 | 16 | 0.25–64 | 90.4 | 2.7 | 6.9 | 85.9 | 4.5 | 9.6 |
Colistin | 12449 | 1 | 2 | 0.06–16 | 96.6 | 0 | 3.4 | 96.6 | 0 | 3.4 |
Aztreonam | 16014 | 8 | 32 | 0.015–256 | NA | NA | NA | 3.9 | 73.4 | 22.8 |
Acinetobacter baumannii | ||||||||||
Ceftaroline | 3567 | 256 | 256 | 0.015–256 | NA | NA | NA | NA | NA | NA |
Ceftazidime–avibactam | 3567 | 32 | 128 | 0.03–256 | NA | NA | NA | NA | NA | NA |
Ceftazidime | 3567 | 64 | 256 | 0.015–256 | 30.1 | 2.4 | 67.5 | NA | NA | NA |
Cefepime | 3567 | 32 | 32 | 0.12–32 | 29.9 | 10.4 | 59.7 | NA | NA | NA |
Pip-taz | 3567 | 256 | 256 | 0.25–256 | 25.4 | 3.7 | 70.9 | NA | NA | NA |
Doripenem | 3567 | 8 | 16 | 0.015–16 | 33.2 | 1.4 | 65.4 | 30.4 | 2.8 | 66.8 |
Imipenem | 3567 | 16 | 16 | 0.03–16 | 33.8 | 1.2 | 65.0 | 33.8 | 2.7 | 63.5 |
Meropenem | 3567 | 16 | 16 | 0.015–16 | 32.8 | 1.6 | 65.6 | 32.8 | 3.5 | 63.7 |
Levofloxacin | 3567 | 8 | 16 | 0.03–16 | 29 | 9.6 | 61.4 | 26.1 | 1.0 | 73 |
Tigecycline | 3567 | 1 | 2 | 0.015–16 | NA | NA | NA | NA | NA | NA |
Amikacin | 3567 | 64 | 64 | 0.25–64 | 42.5 | 5.8 | 51.7 | 40.2 | 2.3 | 57.5 |
Colistin | 2404 | 1 | 2 | 0.06–16 | 94.3 | 0 | 5.7 | 94.3 | 0 | 5.7 |
Aztreonam | 3567 | 64 | 256 | 0.015–256 | NA | NA | NA | NA | NA | NA |