Table 2 The segmented regression analysis of intervention on antibiotic consumption

 Systemic antibiotics

10.7777*** (9.51, 12.05)

0.0237 (− 0.06, 0.10)

− 2.4518** (− 4.14, − 0.76)

− 0.1193* (− 0.22, − 0.02)

2.0572

 Penicillins

4.8920***

(4.22, 5.56)

0.0124

(− 0.03, 0.05)

− 1.9109*** (− 2.80, − 1.02)

−0.0553* (− 0.11, − 0.00)

1.9703

 Cephalosporins

3.1150***

(2.75, 3.48)

− 0.0015

(− 0.02, 0.02)

− 0.0262 (− 0.51,0.45)

−0.0294*

(− 0.06, − 0.00)

2.2194

 Macrolides/lincosamides/ streptogramins

0.9053***

(0.75, 1.06)

0.0099*

(0.00, 0.02)

− 0.2248*

(− 0.43, − 0.02)

− 0.0182** (− 0.03, − 0.01)

1.9409

 Quinolones

1.0594***

(0.93, 1.19)

−0.0005

(− 0.01, 0.01)

− 0.2019* (− 0.37, − 0.03)

− 0.0077 (− 0.02,0.00)

2.0270

 ß-lactamse-sentitive penicillins

7.2141***

(5.86, 8.57)

0.0271

(− 0.06, 0.11)

− 2.9126** (− 4.55, − 1.27)

− 0.0825 (− 0.19, 0.03)

2.0439

 Combinations of penicillins with ß-lactamase inhibitors

2.6349***

(1.71, 3.56)

0.0312

(−0.03, 0.09)

1.2010 (− 0.01, 2.41)

0.0618 (− 0.01, 0.13)

1.9534

 Third and fourth generation cephalosporins

16.2036***

(13.55, 18.85)

−0.1312

(− 0.30, 0.03)

5.0352** (1.55, 8.52)

0.1543 (− 0.05, 0.36)

1.9815

 Fluoroquinolones

9.7988***

(9.31, 10.29)

−0.0246

(− 0.05, 0.01)

0.2156 (− 0.42, 0.85)

0.0406* (0.00, 0.08)

1.8880

 Broad

3.6089***

(3.16, 4.06)

0.0148

(−0.01, 0.04)

−0.1212 (− 0.72, 0.48)

−0.0423* (− 0.08, − 0.01)

2.2142

 Narrow

1.4481***

(1.24, 1.65)

0.0055

(− 0.01, 0.02)

− 0.6449*** (− 0.92, − 0.37)

− 0.0223** (− 0.04, − 0.01)

1.9398

 Broad /Narrow

2.4977***

(1.65, 3.34)

0.0032

(− 0.05, 0.06)

1.8747** (0.78, 2.97)

0.0500 (− 0.02, 0.12)

1.9345

 Oral

5.6076***

(4.73, 6.48)

0.0221

(− 0.03, 0.08)

−1.9292** (−3.09, − 0.77)

−0.0815* (− 0.15, − 0.01)

1.9424

 Parenteral

5.1721***

(4.63, 5.71)

0.0011

(− 0.03, 0.03)

−0.5049 (− 1.22, 0.21)

−0.0373 (− 0.08, 0.00)

2.2052