Table 1 Mutations in QRDR genes in evolved, resistant P. aeruginosa, selected by ciprofloxacin
From: Development of in vitro resistance to fluoroquinolones in Pseudomonas aeruginosa
Passage | Lineage1 | Lineage2 | Lineage3 | Lineage4 | Lineage5 | Lineage6 |
|---|---|---|---|---|---|---|
0. (0MIC) | – | – | – | – | – | – |
1. (1/2MIC) | – | – | – | – | – | – |
2. (1MIC) | – | A87 + B | A87 | – | – | – |
3. (2MIC) | A83 | A87 + B | A87 | – | – | – |
4. (4MIC) | A83 | A87 + B | A87 | A83 | – | A87* |
5. (8MIC) | A83 | A87 + B | A87 | A83 | – | A87* |
6. (16MIC) | A83 | A87 | A87 + B | A83 | / | / |
7. (32MIC) | A83 | / | / | A83 | / | / |
8. (64MIC) | A83 | / | / | A83 | / | / |