Table 1 Baseline characteristics of patients with polymicrobial and monomicrobial Staphylococcus aureus bloodstream infection
Characteristics | Total (n = 349) | Mono-SA-BSI (n = 295) | Poly-SA-BSI (n = 54) | p-value |
|---|---|---|---|---|
Age, median years (IQR) | 59.00 (45.50,68.00) | 60.00 (48,68.00) | 51.00 (40.50,69.00) | 0.06 |
Male sex | 243 (69.6%) | 202 (68.5%) | 41 (75.9%) | 0.27 |
Co-morbidities | ||||
 Diabetes mellitus | 70 (20.1%) | 61 (20.7%) | 9 (16.7%) | 0.50 |
 Chronic kidney disease | 31 (8.9%) | 27 (9.2%) | 4 (7.4%) | 0.88 |
 Chronic liver disease | 16 (4.6%) | 14 (4.7%) | 2 (3.7%) | 1 |
 COPD or Severe asthma | 7 (2%) | 7 (2.4%) | 0 (0%) | 0.60 |
 Chronic cardiac insufficiency | 25 (7.2%) | 22 (7.5%) | 3 (5.6%) | 0.83 |
 Solid tumor | 57 (16.3%) | 48 (16.3%) | 9 (16.7%) | 0.94 |
 Trauma | 73 (20.9%) | 54 (18.3%) | 19 (35.2%) | 0.01 |
 Burn injury | 45 (12.9%) | 30 (10.2%) | 15 (27.8%) | 0.00 |
 Cerebrovascular accident | 39 (11.2%) | 28 (9.5%) | 11 (20.4%) | 0.02 |
CCI, median (IQR) | 3 (1,5) | 3 (2,5) | 2 (1,4.25) | 0.08 |
APACHE II score, median (IQR) | 12 (9,17) | 12 (8,16) | 15 (11,22) | 0.00 |
SOFA score, median (IQR) | 4 (2,6) | 3 (2,5) | 5 (2.75,10) | 0.01 |
Pitt Bacteremia Score, median (IQR) | 2 (1,4) | 1 (1,3) | 3.5 (2,6) | 0.00 |
Hospitalization ward | ||||
 ICU stay | 131 (37.5%) | 93 (31.5%) | 38 (70.4%) | 0.00 |
Previous treatment | ||||
 Parenteral nutrition | 122 (35%) | 91 (30.8%) | 31 (57.4%) | 0.00 |
 Mechanical ventilation | 112 (32.1%) | 76 (25.8%) | 36 (66.7%) | 0.00 |
 Antibiotic exposure | 302 (86.5%) | 251 (85.1%) | 51 (94.4%) | 0.06 |
 Surgery | 124 (35.5%) | 92 (31.2%) | 32 (59.3%) | 0.00 |
 Chemotherapy/radiation | 13 (3.7%) | 13 (4.4%) | 0 (0%) | 0.23 |
 Renal replacement therapy | 43 (12.3%) | 37 (12.5%) | 6 (11.1%) | 0.77 |
 Blood transfusion | 58 (16.6%) | 37 (12.5%) | 21 (38.9%) | 0.00 |
Invasive devices | ||||
 central line catheter | 167 (47.9%) | 132 (44.7%) | 35 (64.8%) | 0.01 |
 Indwelling urinary catheter | 175 (50.1%) | 132 (44.7%) | 43 (79.6%) | 0.00 |
 Intraperitoneal drainage | 33 (9.5%) | 26 (8.8%) | 7 (13%) | 0.34 |
Prior hospital stay, median days (IQR) | 8 (2,20) | 7 (1,19) | 13 (7,32.5) | 0.00 |
Nosocomial infection | 266 (76.2%) | 214 (72.5%) | 52 (96.3%) | 0.00 |
Neutropenia | 7 (2.0%) | 6 (2.0%) | 1 (1.9%) | 1 |