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Table 2 Interrupted time-series regression analysis of antibiotic consumption (carbapenems and all antibiotics) and antibiotic free-days in vascular and general surgery wards (Adjusted for the proportion of men, age distribution, length of stay and seasonality)

From: Persuasive antimicrobial stewardship intervention in the context of a KPC outbreak: a controlled interrupted time series analysis

 

Vascular Surgery

General Surgery

Coefficient (95%CI)

p-value

Coefficient (95%CI)

p-value

Carbapenem consumption (DDD/100 PD)

 Baseline level (β0)*

19.38 (16.36; 22.39)

 

8..60 (7.47; 9.72)

 

 Pre-intervention slope (β1)

−0.16 (− 0.28; − 0.04)

0.008

− 0.05 (− 0.11; 0.00)

0.059

 Level change (post intervention)  (β2)

−11.14 (− 16.18; − 6.10)

< 0.001

−1.88 (− 4.18; 0 .43)

0.109

 Slope post-intervention (β3)

0.15 (− 0.01; 0.31)

0.063

0.06 (− 0.07; 0.19)

0.352

Overall antibiotic consumption (DDD/100 PD)

 Baseline level (β0) *

56.00 (52.22; 59.78)

 

48.04 (48.80; 51.26)

 

 Pre-intervention slope (β1)

0.10 (−0.09; 0.29)

0.302

−0.04 (− 0.18; 0.09)

0.524

 Level change (post intervention)  (β2)

2.73 (−7.95; 13.42)

0.611

−0.30 (−4.30; 3.70)

0.880

 Slope post-intervention (β3)

−1.07 (−1.54; −0.61)

< 0.001

0 .45 (0 .21; 0 .68)

< 0.001

Days without antibiotic (%)

 Baseline level (β0) *

40.87 (38.06; 43.67)

 

54.38 (52.33; 56.44)

 

 Pre-intervention slope (β1)

0.12 (−0.01; 0.26)

0.076

0.12 (0 .03; 0.20)

0.010

 Level change (post intervention)  (β2)

3.18 (−1.86; 8.22)

0.211

−1.46 (−3.56; 0 .62)

0.165

 Slope post-intervention (β3)

0.13 (−0.17; 0.42)

0.395

−0.16 (− 0.31; − 0.02)

0.028