Variable | Base-case value | Range | Range Type | Standard Error | Distribution | Source |
---|---|---|---|---|---|---|
VRE-Related Parameters | ||||||
 Beta, basic reproductive number | 1.32 | 1.03–1.46 | Full | 0.12 | Gamma | Satilmis 2016 [13] |
 VRE prevalence, general | 0.023 | 0–0.18 | Full | 0.001 | Beta | Williams 2015 [14] |
 VRE prevalence, high-risk patients | 0.092 | 0–0.36 | Plausible | 0.002 | Beta | Conly 2001 [15] |
 LOS | without VRE infection, days | 3 | 1.0–6.0 | Full (IQR) | 0.38 | Gamma | Johnstone 2018 [2] |
 LOS | other VRE infection, days | 6 | 1.0–6.0 | Full (IQR) | 0.77 | Gamma | Assumption; Johnstone 2018 [2] |
 LOS | VRE-bacteremia, days | 39 | 22.0–81.0 | Full (IQR) | 4.97 | Gamma | Johnstone 2018 [2] |
Screening Parameters | ||||||
 Sensitivity, rectal swab | 0.991 | 0.95–1.00 | Full | 0.02 | Beta | Stamper 2010 [16] |
 Specificity, rectal swab | 0.949 | 0.92–0.97 | Full | 0.01 | Beta | Stamper 2010 [16] |
 Effectiveness of isolation | 1.00 | 0.75–1.00 | Plausible | – |  | Assumption |
 Discount rate, annual | 0.015 | 0–0.03 | Full | – | – | CADTH 2017 [11] |
Patient Parameters and Transition Probabilities | ||||||
 Average age high-risk, years | 61 | – | – | 1.15 | Normal | Johnstone 2018 [2] |
 Probability infected | colonised | 0.025 | 0.018–0.031 | Plausible | 0.003 | Beta | Williams 2015 [14] |
 Probability bacteremia | infected | 0.155 | 0.12–0.19 | Plausible | 0.02 | Beta | Saunders 2004 [17] |
 Odds ratio bacteremia | infected, high-risk | 1.55 | 0.56–4.29 | Full | 1.68 | Lognormal | Johnstone 2018 [2] |
 Average days of treatment for BSI | 14 | 11–18 | Plausible | 1.79 | Gamma | Daneman 2016 [18] |
 Average days of treatment for other infections | 7 | 5–9 | Plausible | 0.89 | Gamma | Daneman 2016 [18] |
 Probability of death from VRE bacteremia, average, 14 days | 0.37 | 0.27–0.46 | Plausible | 0.05 | Beta | Billington 2014 [19] |
 Probability of death from VRE bacteremia, high-risk, 14 days | 0.46 | 0.35–0.58 | Plausible | 0.06 | Beta | Linden 1996 [20] |
 Number of room visits by all HCW, per day | 24 | 18–30 | Plausible | 3.06 | Normal | Assumption |
Costs | ||||||
 Rectal swab screen | 3.13 | 2.35–3.91 | Plausible | 0.40 | Gamma | Muto 2002 [9] |
 Culture, positive test | 21.36 | 16.02–26.7 | Plausible | 2.72 | Gamma | Muto 2002 [9] |
 Culture, negative test | 8.97 | 6.73–11.21 | Plausible | 1.14 | Gamma | Muto 2002 [9] |
 PPE, per room visit | 2.10 | 1.58–2.63 | Plausible | 0.27 | Gamma | Muto 2002 [9] |
 Nurse time, per test | 7.12 | 5.34–8.9 | Plausible | 0.91 | Gamma | Muto 2002 [9] |
 Private room, daily | 290 | 245–410 | Full | – | – | St. Joseph’s Hospital 2017 [21] |
 Antibiotics, bacteremia, daily | 524.22 | 393.17–655.28 | Plausible | 66.87 | Gamma | Nasr 2011 [22] |
 Antibiotics, other infections, daily | 35.8 | 26.85–44.75 | Plausible | 4.57 | Gamma | Nasr 2011 [22] |
Utilities | ||||||
 VRE bacteremia | 0.56 | 0.51–0.61 | Full | 0.023 | Beta | Lee 2010 [23] |
 Other local infections (UTI) | 0.60 | 0.58–0.62 | Full | 0.01 | Beta | Haran 2005 [24] |
 Inpatient | 0.642 | 0.54–0.74 | Full | 0.05 | Beta | |
 Mild depression, no treatment | 0.88 | 0.84–0.92 | Full | 0.02 | Beta | Revicki 1997 [27] |
 Well, chronic conditions, recovered from previous VRE-related infection | 0.86 | 0.34–0.89 | Full | 0.15 | Beta | Mittmann 1999 [28] |
 Well, chronic conditions, no previous VRE-related infection | 0.93 | 0.88–0.94 | Full | 0.083 | Beta | Mittmann 1999 [28] |