Antimicrobial susceptibility and molecular characteristics of Mycoplasma pneumoniae isolates across different regions of China

Table 3 Genotype characteristics and MIC ranges of four antimicrobial agents against 154 M. pneumoniae clinical isolates from five areas, 2017 to 2018

Region	Mutation in the 23S rRNA	Isolates number		MIC (μg/ml)
Region	Mutation in the 23S rRNA	Genotype I	Genotype II	ERY	AZM	LVX	TET
Beijing	A2063G	30	4	128- > 256	2–32	0.125–1	0.016–0.125
Beijing	None	1	16	< 0.008	< 0.008	0.125–0.5	0.032–0.125
Jilin, Jilin	A2063G	48	0	128- > 256	2–32	0.125–0.5	0.016–0.25
Jilin, Jilin	A2064G	1	0	> 256	2	0.5	0.125
Soochow, Jiangsu	A2063G	22	0	≥256	2–16	0.125–1	0.016–0.125
Soochow, Jiangsu	None	0	2	< 0.008	< 0.008	0.25–0.5	0.032
Jinan, Shangdong	A2063G	8	3	128- > 256	2–32	0.125–1	0.032–0.125
	A2064G	1	0	256	2	0.5	0.032
	None	1	9	< 0.008	< 0.008	0.125–0.5	0.016–0.125
Fuyang, Anhui	A2063G	6	0	> 256	4–16	0.125–0.5	0.032–0.125
Fuyang, Anhui	None	0	2	< 0.008	< 0.008	0.25–0.5	0.032–0.125
Total	A2063G	114	7	128- > 256	2–32	0.125–1	0.016–0.25
	A2064G	2	0	≥256	2	0.5	0.032–0.125
	None	2	29	< 0.008	< 0.008	0.125–0.5	0.016–0.125

The MIC of each agent was defined as the lowest concentration of each antibiotic that prevented the color change
ERY erythromycin, AZM azithromycin, LVX levofloxacin, TET tetracycline

ISSN: 2047-2994