Evaluation of accordance of antibiotics package size with recommended treatment duration of guidelines for sore throat and urinary tract infections

Table 2 Accordance of the package sizes of selected drugs with guidelines for sore throat II

Drug	Package size	ISKRA^a	Min No. of Packages	Extra units	IDSA^b	Min No. of Packages	Extra units	NICE^c	Min No. of Packages	Extra units
Clarithromycin	14x250 mg^d	2x250 mg, 10 days	2	8	2x250 mg, 10 days	2	8	2x250-500 mg, 5 days	1	4
	5x500 mg	2x250 mg, 10 days	n/a		2x250 mg, 10 days	n/a		2x250-500 mg, 5 days	2	0
	7x500 mg^d	2x250 mg, 10 days	n/a		2x250 mg, 10 days	n/a		2x250-500 mg, 5 days	2	4
	14x500 mg^d	2x250 mg, 10 days	n/a		2x250 mg, 10 days	n/a		2x250-500 mg, 5 days	1	4
Penicillin V	30x1000000 IU^d	3x1 500 000 IU, 10 days	2	15	4x250 mg, 10 days	n/a		4x500 mg, 5-10 days	n/a
	30x1000000 IU^d	3x1 500 000 IU, 10 days	2	15	2x500 mg, 10 days	n/a		2x1000 mg, 5-10 days	n/a
	30x1500000 IU^d	3x1 500 000 IU, 10 days	1	0	4x250 mg, 10 days	n/a		4x500 mg, 5-10 days	n/a
	30x1500000 IU^d	3x1 500 000 IU, 10 days	1	0	2x500 mg, 10 days	n/a		2x1000 mg, 5-10 days	n/a
Erythromycin	16x250 mg^d	n/a			n/a			4x250-500 mg, 5 days	3	8
Erythromycin	16x250 mg^d	n/a			n/a			2x500-1000 mg, 5 days	3	8

n/a – not applicable; IU-international unit; extra units of drugs are presented with reference to the original formulation
^aThe Intersectoral Society for Antibiotic Resistance Control (ISKRA) guidelines on sore throat: diagnostic and therapeutic approach – Croatian national guidelines
^bClinical Practice Guideline for the Diagnosis and Management of Group A Streptococcal Pharyngitis: 2012 Update by the Infectious Diseases Society of America
^cNational Institute for Health and Care Excellence (NICE) Sore throat (acute): antimicrobial prescribing
^dincluded in Croatian national reimbursement lists on 1^st of August 2018

ISSN: 2047-2994