Table 3 Epidemiology of oqxAB in Klebsiella pneumoniae
From: The nature and epidemiology of OqxAB, a multidrug efflux pump
References | Bacterial species | Year(s) of isolates collection | Geographic area | Sample source | Percentage of oqxAB carring isolates (no. of isolates) | Resistance phenotype(s) | Descriptions |
|---|---|---|---|---|---|---|---|
[19] | K. pneumoniae | 1998–2006 | Seoul Korea | Human | K. pneumoniae: 74.1% (100/135) | OLA, CIP | This is the first report of the presence of an oqxAB-containing plasmid in a human isolate of E. coli. |
[14] | K. pneumoniae Klebsiella spp. | 2010 | Shanghai China | Human | K. pneumoniae: 100% (154/154) | NAL, CIP, NOR, LVX, OLA, TMP, CHL, TET | Variants of oqxA2, oqxB2 and oqxB3 were identified. |
[67] | K. pneumoniae | 2005–2010 | Seoul, Korea | Human | K. pneumoniae: 10.8% (11/102) | NAL, LVX, AK, GEN, TOB | The oqxAB gene was only found in K. pneumoniae isolates. |
[71] | K. pneumoniae, | 2010 | Tunis | Human | K. pneumoniae: 65% (26/40) | GEN, TOB, AK, NAL, CIP, SXT | The prevalence of PMQR determinants among ESBL-producing strains |
[8] | K. pneumoniae | 2012 | Northeast Ohio | Human | K. pneumoniae: 100% (36/36) | CIP | KPC-2 and KPC-3 types β-lactamase (bla) genes |
[8] | K. pneumoniae | 2006–2009 | New York, New Jersey, Pennsylvania | Human | K. pneumoniae: 83.3% (5/6) | CIP | KPC-2 and KPC-3 types β-lactamase (bla) genes |
[8] | K. pneumoniae | 1996–1997 | Taiwan, Turkey, Australia, South Africa, Argentina, Belgium, the US | Human | K. pneumoniae: 87.5% (14/16) | – | TEM-10, SHV-2, SHV-5, CTX-M-2, CTX-M-3 types β-lactamase (bla) genes |
[68] | K. pneumoniae | 2012–2014 | Jiangsu, China | Human | K. pneumoniae: 67.6% (50/74) | AK, Q | Novel mutants (oqxA11, oqxB13, oqxB27, and oqxB28) were identified. |
[69] | K. pneumoniae | 2014–2015 | Tehran, Iran | Human | oqxA: 56.7% (140/247), oqxB: 54.6% (135/247) | CAZ, NOR, CTX, CPD, NAL, CIP, GEN, TGC,AK | The predominant coexisting ESBL and PMQR profile among our isolates included blaCTX-M and aac(6′)-Ib, oqxA, oqxB (28.3%) and blaTEM, blaSHV and aac(6′)-Ib, oqxA, and oqxB (19.4%) profile. |