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Table 1 Genotype characteristics and MIC ranges of four antimicrobial agents used against 81 M. pneumoniae clinical isolates from 2014 to 2016

From: Antimicrobial susceptibility and genotyping of Mycoplasma pneumoniae isolates in Beijing, China, from 2014 to 2016

Year

Mutation in the 23S rRNA

Isolates number

MLVA genotype (Numbers)

No. of “AGT” VNTRs repeats in p1 gene (Number)

MIC (μg/ml)

type1

type2

type1

type2

type1

type2

ERY

AZM

LVX

TET

2014

A2063G

13

2

4/5/7/2 (10)

4/5/7/3 (2)

4/4/7/2 (1)

3/5/6/2 (2)

5 repeats(1)

7 repeats(6)

8 repeats(5)

11repeats(1)

6 repeats(1)

8 repeats(1)

≥256

2–32

0.25–1

0.016–0.25

A2064G

1

0

4/5/7/2 (1)

0

7 repeats(1)

 

≥256

4

0.25

0.032

None

2

9

4/5/7/2 (2)

3/5/6/2 (9)

5 repeats(1)

7 repeats(1)

6 repeats(3)

7 repeats(2)

8 repeats(3)

12 repeats(1)

≤0.008

≤0.008

0.25–1

0.032–0.25

2015

A2063G

12

2

4/5/7/2 (12)

3/5/6/2 (2)

4 repeats(1)

6 repeats(5)

7 repeats(4)

8 repeats(2)

8 repeats(2)

≥256

2–64

0.125–0.5

0.032–0.5

None

0

5

0

3/5/6/2 (5)

0

5 repeats(1)

8 repeats(4)

≤0.008

≤0.008

0.25–1

0.032–0.25

2016

A2063G

19

4

4/5/7/2 (17)

4/5/7/3 (2)

3/5/6/2 (3)

3/5/7/2 (1)

6 repeats(2)

7 repeats(5)

8 repeats(4)

9 repeats(6)

10 repeats(1)

12 repeats(1)

7 repeats(3)

10 repeats(1)

≥256

2–64

0.125–1

0.016–0.5

None

0

12

0

3/5/6/2 (11)

3/5/7/2 (1)

0

6 repeats(2)

7 repeats(5)

8 repeats(3)

10 repeats(1)

14 repeats(1)

≤0.008

≤0.008

0.25–1

0.032–0.5

  1. The MIC of each agent was defined as the lowest concentration of each antibiotic that prevented the color change
  2. ERY erythromycin, AZM azithromycin, LVX levofloxacin, TET tetracycline