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Table 3 Benefits and Costs of a Comprehensive CDI Prevention Program 2015–2020 (2015 $)

From: Assessing the social cost and benefits of a national requirement establishing antibiotic stewardship programs to prevent Clostridioides difficile infection in US hospitals

 

7% discount rate, 10% effectiveness

3% discount rate, 10% effectiveness

7% discount rate, 50% effectiveness

3% discount rate, 50% effectiveness

Total Intervention Costs (in billions)

$3.7

$4.7

$3.3

$4.2

Total Benefits (in billions)

Direct Medical Cost Savings

  Savings in Patient Care Costs

$1.5

$1.8

$7.6

$9.1

  Savings in Hospital Expenditures for Antibiotics

$3.8

$4.2

$3.8

$4.2

Benefits of Morbidity Risk Reduction

  Low $/Lost QALY from HCA-CDI

$0.4

$0.3

$2.1

$1.3

  Central $/ Lost QALY from HCA-CDI

$0.8

$0.6

$4.1

$2.8

  High $/ Lost QALY from HCA-CDI

$1.3

$0.8

$6.3

$4.2

Benefits of Mortality Risk Reduction

 Low VSL

  35% Attributable Mortality Proportion

$22.1

$26.6

$111.2

$133.2

  50% Attributable Mortality Proportion

$31.5

$38.0

$157.7

$190.2

 Central VSL

  35% Attributable Mortality Proportion

$46.6

$56.2

$232.8

$280.8

  50% Attributable Mortality Proportion

$66.5

$80.2

$332.6

$401.1

 High VSL

  35% Attributable Mortality Proportion

$71.1

$85.7

$355.7

$428.7

  50% Attributable Mortality Proportion

$102.7

$122.5

$507.8

$612.5

Range of Total Net Benefits

  Low

$24.1 - $33.5

$28.2 - $ 39.6

$121.4 - $167.9

$143.6 - $200.6

  Central

$49.0 - $68.9

$58.1 - $ 82.1

$245.0 - $344.8

$292.7 - $413.0

  High

$74.0 - $105.6

$87.8 - $124.6

$370.1 - $522.2

$442.0 - $625.8

  1. HCA-CDI healthcare-associated Clostridioides difficile infection, VSL value of a statistical life, QALY quality-adjusted life year.