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Table 2 Results of MIC and antimicrobial susceptibility testing of ceftazidime-avibactam single dosing and combined with aztreonam against NDM + KPC-2 carbapenemase-producing Klebsiella pneumoniae in 30 strains

From: In vitro and in vivo bactericidal activity of ceftazidime-avibactam against Carbapenemase–producing Klebsiella pneumoniae

Strain no.

Bacteria

β-lactamase

MIC(mg/L) single dosing

MIC(mg/L) Combined dosing

FIC value

Associated β-lactamase

ATM

CAZ-AVI

ATM

CAZ-AVI

ATM + CAZ-AVI

R078 Anhui

K. pneumoniae

NDM

256

32

8

1

0.06

SHV-28, DHA-1, CTX-M-15

R080 Hainan

K. pneumoniae

NDM

128

4

32

0.25

0.31

SHV-11, DHA-1, CTX-M-14

R081 Hainan

K. pneumoniae

NDM

1024

8

64

2

0.31

SHV-11, DHA-1, CTX-M-14

R082 Hainan

K. pneumoniae

NDM

256

64

16

1

0.08

SHV-11, DHA-1, CTX-M-15, CTX-M-14

R083 Hainan

K. pneumoniae

NDM

128

64

32

0.5

0.26

SHV-12, DHA-1, CTX-M-15

R084 Hainan

K. pneumoniae

NDM

512

64

16

1

0.05

SHV-12, DHA-1

R085 Hainan

K. pneumoniae

NDM

1024

128

32

2

0.05

SHV-12, DHA-1, CTX-M-15

R086 Hainan

K. pneumoniae

NDM

128

64

16

0.5

0.13

SHV-12, DHA-1, CTX-M-15

R088 Hainan

K. pneumoniae

NDM

32

2

4

0.5

0.38

SHV-11, DHA-1, CTX-M-14

R093 Hebei

K. pneumoniae

NDM

32

64

4

0.5

0.13

SHV1, DHA-1, CTX-M-14

R094 Hebei

K. pneumoniae

NDM

32

64

8

0.25

0.25

SHV-12, DHA-1, CTX-M-14

R095 Hebei

K. pneumoniae

NDM

32

2

8

0.25

0.38

SHV-12, DHA-1, CTX-M-15

R096 Henan

K. pneumoniae

NDM

16

64

16

0.5

1.01

SHV1, DHA-1, CTX-M-15

R097 Henan

K. pneumoniae

NDM

8

256

4

128

1.00

SHV1, DHA-1, CTX-M-14

R098 Henan

K. pneumoniae

NDM

256

64

32

1

0.14

DHA-1

R100 Shanxi

K. pneumoniae

NDM

8

32

4

32

1.50

SHV-78, DHA-1, CTX-M-14

R101 Shanxi

K. pneumoniae

NDM

256

128

16

1

0.07

SHV-78, DHA-1, CTX-M-14

R102 Shanxi

K. pneumoniae

NDM

32

256

4

1

0.13

SHV-78, DHA-1, CTX-M-14

R103 Shanxi

K. pneumoniae

NDM

128

64

32

0.25

0.25

SHV1, DHA-1, CTX-M-15

R106 Sanxi

K. pneumoniae

NDM

128

64

8

1

0.08

SHV-12, DHA-1

R110 Sanxi

K. pneumoniae

NDM

128

256

8

1

0.07

SHV-12, DHA-1

R113 Sanxi

K. pneumoniae

NDM

128

64

16

0.5

0.13

SHV-12, DHA-1

R122 Tianjin

K. pneumoniae

NDM

32

1

4

0.25

0.38

SHV-12, DHA-1, CTX-M-14

R126 Tianjin

K. pneumoniae

NDM

512

64

16

1

0.05

SHV-12, DHA-1, CTX-M-14

R127 Tianjin

K. pneumoniae

NDM

256

128

32

1

0.13

SHV2, DHA-1

R128 Zhejiang

K. pneumoniae

NDM

128

256

8

2

0.07

SHV1, DHA-1

R129 Zhejiang

K. pneumoniae

NDM

4

0.5

0.5

0.125

0.38

SHV-12, DHA-1, CTX-M-15

R136 Zhejiang

K. pneumoniae

NDM

256

64

16

1

0.08

SHV-12, DHA-1

R148 Tianjing

K. pneumoniae

KPC-2,NDM

2048

8

256

2

0.38

SHV-12, DHA-1, CTX-M-14

R153 Henan

K. pneumoniae

KPC-2,NDM

2048

128

128

8

0.13

SHV-12, DHA-1

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Antimicrobial Resistance & Infection Control

ISSN: 2047-2994

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