In vitro and in vivo bactericidal activity of ceftazidime-avibactam against Carbapenemase–producing Klebsiella pneumoniae

Table 1 Minimal inhibitory concentration (MIC) of ceftazidime-avibactam against KPC-2 or OXA-232 carbapenemase-producing Klebsiella pneumoniae

Strain no.	Bacteria	β-lactamase	MIC (mg/L)				Associated β-lactamase
Strain no.	Bacteria	β-lactamase	CAZ-AVI	CAZ	IPM	MEM	Associated β-lactamase
R16- Hefei	K. pneumoniae	KPC-2	8	128	64	64	CTX-M-14, SHV-11, DHA-1
R18- Hefei	K. pneumoniae	KPC-2	4	128	8	16	SHV-28, DHA-1
R19- Hefei	K. pneumoniae	KPC-2	4	128	16	16	SHV-12, DHA-1
R31- Beijing	K. pneumoniae	KPC-2	8	128	64	256	SHV-11, DHA-1
R35- Beijing	K. pneumoniae	KPC-2	8	128	128	256	SHV-11, DHA-1
R39-Fuzhou	K. pneumoniae	KPC-2	8	> 256	32	64	CTX-M-14, SHV-12, DHA-1
R42- Fuzhou	K. pneumoniae	KPC-2	8	> 256	32	64	CTX-M-14, SHV-12, DHA-1
R44- Fuzhou	K. pneumoniae	KPC-2	8	> 256	64	128	CTX-M-14, SHV-12, DHA-1
R46- Fuzhou	K. pneumoniae	KPC-2	8	> 256	64	64	SHV-12, DHA-1
R52- Fuzhou	K. pneumoniae	KPC-2	8	> 256	64	128	CTX-M-14, SHV-12, DHA-1
R53- Fuzhou	K. pneumoniae	KPC-2	8	> 256	64	128	CTX-M-14, SHV-12, DHA-1
R59- Hangzhou	K. pneumoniae	KPC-2	8	32	8	16	CTX-M-14, SHV-11, DHA-1
R60- Hangzhou	K. pneumoniae	KPC-2	4	32	4	4	CTX-M-14, SHV-11, DHA-1
JSD-Shanghai	K. pneumoniae	KPC-2	8	128	128	512	CTX-M-14, SHV-11, DHA-1
WJQ-Shanghai	K. pneumoniae	KPC-2	8	> 256	128	256	CTX-M-14, SHV-11, DHA-1
LDX-Shanghai	K. pneumoniae	KPC-2	8	> 256	32	64	CTX-M-55, SHV-31, DHA-1
PED-Shanghai	K. pneumoniae	OXA-232	2	> 32	1	4	CTX-M-15, SHV-1

Note: CAZ-AVI Ceftazidime-avibactam, CAZ Ceftazidime, IPM Imipenem, MEM Meropenem

ISSN: 2047-2994