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Table 2 Univariate and multivariate analyses of factors potentially related to antibiotic prophylaxis-resistant surgical site infections (Logistic regression analysis; results expressed as odds ratios with 95% confidence intervals)

From: Should antibiotic prophylaxis before orthopedic implant surgery depend on the duration of pre-surgical hospital stay?

Total n = 611

Univariate analysis

Multivariate analysis

Female sex

1.0, 0.7–1.4

n.d.

Age

1.0, 1.0–1.0

1.0, 1.0–1.0

Past history of MRSAb body carriage

1.3, 1.1–2.9

1.4, 1.1–3.3

Immune suppressiona

0.7, 0.5–1.1

n.d.

- Diabetes mellitus

0.7, 0.4–1.2

n.d.

Shoulder implants

0.5, 0.2–1.5

n.d.

Arthroplasties

1.1, 0.8–1.8

1.2, 0.8–1.9

Spondylodeses

1.4, 0.7–2.9

1.4, 0.6–3.1

Plates

1.0, 0.6–1.5

n.d.

Intramedullary nails

1.2, 0.6–2.3

1.3, 0.6–2.6

Foot osteosyntheses

0.7, 0.3–1.6

0.8, 0.3–1.9

Duration of prior hospital stay

1.0, 1.0–1.0

1.0, 1.0–1.0

- 10–20 days compared to ≤10 days

1.1, 0.5–2.4

1.2, 0.5–2.5

- ≥ 20 days compared to ≤10 days

1.0, 0.6–1.7

1.1, 0.4–3.3

  1. n d. = not done
  2. *Statistically significant results are displayed in bold and italic
  3. aImmune suppression = diabetes mellitus, corticosteroid medication, organ transplantation, cirrhosis CHILD C, dialysis, or active cancer
  4. bMethicillin-resistant Staphylococcus aureus