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Table 4 Local targets set by study intervention wards and outcome for targeted change in prescribing practice

From: The effect of antibiotic stewardship interventions with stakeholder involvement in hospital settings: a multicentre, cluster randomized controlled intervention study

Hospital

Ward

Intervention

Targets

Outcome

A

Pulmonary medicine

Audit with feedback

Increase the use of Penicillin G 2 mill IU ×  4 to treat pneumonia (CAP) and infectious COPD exacerbations

30% increase (p < 0.001)a

A

Gastroenterology

Academic detailing

Reduce ciprofloxacin use for inflammatory bowel disease, and shift to Co-trimoxazol

(indication outside national antibiotic guideline)

Too few patients with targeted indication to assess outcome by indication.

Assessed by use of sales statistics. Reduction in use of Ciprofloxacin at 3, 6, 12 and 18 months following the intervention (not significant)b (Appendix Table 6).

B

Pulmonary medicine

Academic detailing

Target areas discussed:

- Reevaluation of initiated treatment on arrival to ward and - after 48–72 h

- Increase use of CRB-65 and antibiotic guideline

Consensus on 1–2 targets not achieved

B

Infectious diseases

Audit with feedback

Target areas discussed:

- Increase use of Penicillin G 2 mill × 4 to treat infectious COPD exacerbations

- Reassess length of iv-antibiotics for patients with osteomyelitis

- Increase consultants presence in the emergency room to increase guidelines adherence on admission

- Reevaluation of treatment during the patient stay

Consensus on 1–2 targets not achieved

C

Infectious diseases

Academic detailing

No target area identified.

No target area identified

  1. aBy chi-square test bBy Interrupted time series analysis (Appendix Table 6)