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Table 5 Univariate and multivariate cox regression analysis for the risk for mortality after discharge from index hospitalization

From: Risk for subsequent infection and mortality after hospitalization among patients with multidrug-resistant gram-negative bacteria colonization or infection

 

All-cause mortality

MDRGNB infection-associated mortality

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

HR

(95% CI)

p-value

HR

(95% CI)

p-value

HR

(95% CI)

p-value

HR

(95% CI)

p-value

Age (per year increase)

1.02

(1.01–1.03)

0.001

1.02

(1.01–1.03)

0.006

1.04

(1.02–1.06)

< 0.001

1.03

(1.01–1.05)

0.008

Male sex

1.34

(0.96–1.88)

0.09

1.24

(0.71–2.16)

0.45

LTCF residence

1.33

(0.65–2.71)

0.43

2.37

(0.94–5.95)

0.07

Long-term hemodialysis

1.10

(0.45–2.68)

0.84

1.86

(0.58–5.96)

0.30

Diabetes mellitus

0.89

(0.62–1.29)

0.89

0.93

(0.51–1.72)

0.82

Malignancy

6.28

(4.52–8.73)

< 0.001

5.30

(3.73–7.53)

< 0.001

2.32

(1.32–4.07)

0.004

2.34

(1.28–4.26)

0.006

End-stage renal disease

0.82

(0.34–2.00)

0.82

1.40

(0.44–4.48)

0.57

Liver cirrhosis

1.65

(1.04–2.61)

0.034

0.81

(0.29–2.23)

0.68

Congestive heart failure

1.25

(0.74–2.10)

0.41

2.38

(1.20–4.73)

0.014

COPD

1.40

(0.88–2.25)

0.16

2.62

(1.38–4.99)

0.003

Cerebrovascular accident

0.90

(0.57–1.43)

0.65

1.76

(0.94–3.28)

0.08

High CCI (≥5)

3.33

(2.41–4.60)

< 0.001

1.80

(1.27–2.55)

< 0.001

3.56

(2.08–6.12)

< 0.001

1.96

(1.10–3.49)

0.022

Presence of pressure sore

1.98

(1.13–3.41)

0.016

1.93

(0.77–4.85)

0.16

Central vascular cathetera,b

4.07

(2.66–6.22)

< 0.001

2.80

(1.26–6.21)

0.012

Long-term urinary catheterb

0.35

(0.13–0.94)

0.037

0.29

(0.11–0.80)

0.017

0.49

(0.12–2.02)

0.33

Antibiotics exposurec

1.70

(1.14–2.56)

0.010

3.96

(1.58–9.95)

0.003

MDRGNB culture positivec,d

2.40

(1.66–3.46)

< 0.001

2.42

(1.67–3.50)

< 0.001

5.91

(3.44–10.14)

< 0.001

4.88

(2.79–8.52)

< 0.001

  1. Abbreviations: MDRGNB multidrug-resistant gram-negative bacteria, LTCF long-term care facility, COPD chronic obstructive pulmonary disease, CCI Charlson comorbidity index
  2. aIncluding port-A catheter, Hickman catheter, permcath catheter, double-lumen catheter, and peripherally inserted central catheter
  3. bAt the time of index hospitalization discharge
  4. cDuring index hospitalization
  5. dIncluding positive MDRGNB culture from either surveillance or clinical culture of any anatomical site