Variables | Colonization (n = 66) | No Colonization (n = 73) | p-value |
---|---|---|---|
Female gender (yrs), n (%) | 33 (50.0%) | 37 (50.7%) | 0.94 |
Age (yrs), mean ± SD | 65.7 ± 16.7 | 68.5 ± 15.1 | 0.32 |
Duration from hospital admission to first sample collection (days), median (range) | 16 (1–106) | 16 (2–81) | 0.37 |
Duration from enrollment to first sample collection (days), median (range) | 1 (1–4) | 1 (1–5) | 0.54 |
ICU admission, n (%) | 24 (36.4%) | 24 (32.9%) | 0.67 |
Previous hospitalization, n (%) | 36 (54.5%) | 37 (50.7%) | 0.65 |
APACHE II score at study enrollment, mean ± SD | 21.6 ± 7.1 | 21.9 ± 7.6 | 0.77 |
Mechanical ventilation, n (%) | 59 (89.4%) | 58 (79.5%) | 0.11 |
Indwelling central venous catheter, n (%) | 45 (68.2%) | 40 (54.8%) | 0.11 |
Surgery, n (%) | 45 (68.2%) | 39 (53.4%) | 0.08 |
Chronic intermittent hemodialysis, n (%) | 8 (12.1%) | 10 (13.7%) | 0.78 |
Antibiotic use for the current hospitalization prior to study enrollment and during study period, n (%) | |||
 Carbapenems | 57 (86.4%) | 66 (90.4%) | 0.46 |
 Cephalosporins | 31 (47.0%) | 31 (42.5%) | 0.59 |
 Beta-lactam/ beta-lactamase inhibitors | 54 (81.8%) | 52 (71.2%) | 0.14 |
 Fluoroquinolones | 42 (63.6%) | 33 (45.2%) | 0.03 |
 Vancomycin | 40 (60.6%) | 38 (52.1%) | 0.31 |
 Aminoglycosides | 10 (15.2%) | 2 (2.7%) | < 0.001 |
Antibiotic use for the current hospitalization prior to study enrollment, n (%) | |||
 Carbapenems | 52 (78.8%) | 60 (82.2%) | 0.61 |
 Cephalosporins | 26 (39.4%) | 30 (41.1%) | 0.84 |
 Beta-lactam/beta-lactamase inhibitors | 37 (56.1%) | 38 (52.1%) | 0.64 |
 Fluoroquinolones | 24 (36.4%) | 15 (20.5%) | 0.04 |
 Vancomycin | 22 (33.3%) | 21 (28.8%) | 0.56 |
 Aminoglycosides | 5 (7.6%) | 1 (1.4%) | 0.10 |
Colistin use within 3Â months prior to study enrollment, n (%) | 13 (19.7%) | 2 (2.7%) | 0.001 |
Total amount of colistin (mg), median (range) | 3550 (400–12,550) | 2000 (500–10,650) | < 0.001 |
Total duration of colistin use (days), median (range) | 13.5 (2–58) | 9 (2–32) | < 0.001 |
Total courses of colistin therapy, mean ± SD | 1.4 ± 0.8 | 1.1 ± 0.4 | 0.003 |
Total courses of colistin therapy, range | 1–4 | 1–3 |  |
Patients who received more than 1 course of colistin therapy, n (%) | 19 (28.8%) | 7 (9.6%) | 0.004 |
Length of hospital stay (days), median (range) | 46.5 (12–246) | 32 (6–192) | 0.01 |
All-cause mortality at hospital discharge, n (%) | 35 (53.0%) | 35 (47.9%) | 0.55 |