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Table 3 Cross-correlation coefficients between quarterly antibiotics prescriptions and quarterly isolation rates of antibiotic-resistant K pneumoniae from 2012 to 2016

From: Temporal association between antibiotic use and resistance in Klebsiella pneumoniae at a tertiary care hospital

Antibiotics

Antibiotic-resistant Klebsiella pneumoniae

Piperacillin/tazobactam

Ceftazidime

Levofloxacin

β-lactam/β-lactamase inhibitors

0.66

p < 0.01

2 quarters lag

0.54

p = 0.02

2 quarters lag

−0.60

p = 0.01

2 quarters lag

Third-generation cephalosporins

−0.11

p = 0.65

-

0.64

p < 0.01

2 quarters lag

0.50

p = 0.03

1 quarter lag

Fluoroquinolones

0.26

p = 0.29

-

0.14

p < 0.01

2 quarters lag

0.23

p = 0.35

-