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Table 3 Validity comparisons for Google Trends to detect MRSA outbreaks with SO-ZI/AMR as the reference standard. Day 0 indicates the day the outbreak was reported to SO-ZI/AMR

From: Social media posts and online search behaviour as early-warning system for MRSA outbreaks

Day

Any MRSA outbreak

MRSA outbreak in hospital

AUC

(95% CI)

Optimal cutoffa

Se

Sp

AUC

(95% CI)

Optimal cutoffa

Se

Sp

−7

0.61

(0.54–0.69)

−0.2018

75

47

0.59

(0.51–0.67)

− 0.6507

100

23

−6

0.51

(0.44–0.59)

− 0.1208

63

51

0.51

(0.42–0.59)

−0.6965

93

21

−5

0.46

(0.38–0.55)

−0.4318

71

33

0.48

(0.39–0.58)

−0.8801

97

13

−4

0.50

(0.42–0.58)

−0.5524

81

28

0.53

(0.44–0.62)

−0.5524

87

28

−3

0.46

(0.38–0.54)

−0.5377

81

29

0.48

(0.39–0.58)

−0.5377

87

29

−2

0.52

(0.44–0.61)

0.1445

42

65

0.47

(0.37–0.57)

−0.6828

83

21

−1

0.59

(0.50–0.67)

0.0425

60

61

0.59

(0.47–0.71)

0.0672

67

62

0

0.59

(0.51–0.67)

−0.5524

90

28

0.63

(0.54–0.73)

0.3316

43

79

+ 1

0.54

(0.46–0.63)

−0.1769

63

48

0.49

(0.39–0.59)

−1.1493

100

7

+ 2

0.49

(0.41–0.57)

− 1.1833

100

6

0.46

(0.36–0.55)

−0.9484

97

11

+3

0.50

(0.43–0.58)

−0.5149

79

29

0.56

(0.46–0.66)

−0.1118

63

51

+ 4

0.49

(0.41–0.57)

−0.6828

90

21

0.49

(0.40–0.59)

−0.6828

93

21

+ 5

0.44

(0.37–0.51)

0.1674

15

65

0.39

(0.31–0.47)

−1.3370

100

4

+ 6

0.49

(0.42–0.57)

− 1.0128

98

9

0.47

(0.38–0.57)

−1.0128

97

9

+ 7

0.53

(0.45–0.60)

−0.4993

85

30

0.50

(0.40–0.61)

− 0.5745

83

27

  1. AUC area under the curve, CI confidence interval, Se sensitivity, Sp specificity
  2. aMaximizes sensitivity+specificity. Value represents k