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Table 4 The Asp-87 mutation in gyrA in the four predominate Shigella flexneri serotypes

From: Newest data on fluoroquinolone resistance mechanism of Shigella flexneri isolates in Jiangsu Province of China

Serotypes

Mutation

Years

Total

2012 (%a)

2013 (%b)

2014 (%c)

2015 (%d)

2a (n = 156)

gyrA-Asp87Asn

59.6 (28/47)

53.7 (22/41)

63.6 (21/33)

82.9 (29/35)

64.1 (100/156)

gyrA-Asp87Gly

23.4 (11/47)

9.8 (4/41)

15.2 (5/33)

14.3 (5/35)

16.0 (25/156)

1a (n = 75)

gyrA-Asp87Asn

0.0 (0/25)

10.7 (3/28)

53.8 (7/13)

0.0 (0/9)

13.3 (10/75)

gyrA-Asp87Gly

88.0 (22/25)

39.3 (11/28)

23.1 (3/13)

33.3 (3/9)

52.0 (39/75)

2b (n = 66)

gyrA-Asp87Asn

0.0 (0/21)

10.5 (2/19)

8.3 (1/12)

7.1 (1/14)

6.1 (4/66)

gyrA-Asp87Gly

76.2 (16/21)

68.4 (13/19)

58.3 (7/12)

21.4 (3/14)

59.1 (39/66)

1b (n = 61)

gyrA-Asp87Asn

0.0 (0/20)

0.0 (0/10)

0.0 (0/12)

0.0 (0/19)

0.0 (0/61)

gyrA-Asp87Gly

0.0 (0/20)

0.0 (0/10)

0.0 (0/12)

0.0 (0/19)

0.0 (0/61)

  1. a% = Mutation strains/number of different serotypes in 2012
  2. b% = Mutation strains/number of different serotypes in 2013
  3. c% = Mutation strains/number of different serotypes in 2014
  4. d% = Mutation strains/number of different serotypes in 2015