Table 1 Summary MIC data for nine antimicrobials against 105 Thai C. difficile isolates
From: Antimicrobial susceptibility of Clostridium difficile isolated in Thailand
Antimicrobiala | MIC range (mg/L) | MIC50 (mg/L) | MIC90 (mg/L) | Clinical breakpoints [11] | Susceptible | Intermediate | Resistant | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
S | I | R | N | % | N | % | N | % | ||||
FDX | 0.004–0.25 | 0.06 | 0.25 | – | – | – | – | – | – | – | – | – |
VAN | 0.06–2 | 1 | 2 | ≤2 | – | >2 | 105 | 100.0 | 0 | 0.0 | 0 | 0.0 |
MTZ | 0.015–0.5 | 0.25 | 0.25 | ≤2 | – | >2 | 105 | 100.0 | 0 | 0.0 | 0 | 0.0 |
RFX | 0.008–>16 | 0.015 | >16 | – | – | – | – | – | – | – | – | – |
CLI | 0.015–>32 | 8 | >32 | ≤2 | 4 | ≥8 | 17 | 16.2 | 11 | 10.5 | 77 | 73.3 |
ERY | 0.12–>256 | 2 | >256 | – | – | >8 | – | – | – | – | 37 | 35.2 |
AMC | 0.03–2 | 0.5 | 1 | ≤4 | 8 | ≥16 | 105 | 100.0 | 0 | 0.0 | 0 | 0.0 |
MXF | 0.12–32 | 2 | 16 | ≤2 | 4 | ≥8 | 82 | 78.1 | 1 | 1.0 | 22 | 21.0 |
MEM | 0.25–4 | 2 | 4 | ≤4 | 8 | ≥16 | 105 | 100.0 | 0 | 0.0 | 0 | 0.0 |