Variable | Total (n = 114) n(%) | Death (n = 26) n(%) | Survivors (n = 88) n(%) | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|---|---|---|
OR(95% CI) | p-value | OR(95% CI) | p-value | ||||
General variables | |||||||
 Male sex | 74(64.9) | 20(76.9) | 54(61.4) | 2.10(0.8–5.8) | 0.144 |  |  |
 Age,years, mean ± SD | 56.37 ± 16.36 | 55.54 ± 16.10 | 56.61 ± 16.52 | NA | 0.770 |  |  |
 Poly-microbial BSI | 11(9.6) | 3(11.5) | 8(9.1) | 1.30(0.3–5.3) | 0.711 |  |  |
 Nosocomial infection | 98(86.0) | 23(88.5) | 75(85.2) | 1.33(0.3–5.1) | 1 |  |  |
 ICU acquired infection | 26(22.8) | 10(38.5) | 16(18.2) | 2.81(1.1–7.3) | 0.03 | - | - |
Comorbidities | |||||||
 Diabetes mellitus | 30(26.3) | 4(15.4) | 26(29.5) | 0.43(0.1–1.4) | 0.150 |  |  |
 Chronic renal failure | 8(7.0) | 1(3.8) | 7(8.0) | 0.463(0.05–3.9) | 0.680 |  |  |
 Chronic liver disease | 20(17.5) | 9(34.6) | 11(12.5) | 3.71(1.3–10.3) | 0.017 |  |  |
 Liver cirrhosis | 11(9.6) | 5(19.2) | 6(6.8) | 3.25(0.9–11.7) | 0.122 |  |  |
 Biliary tract disease | 35(30.7) | 8(30.8) | 27(30.7) | 1.00(0.4–2.6) | 1 |  |  |
 Congestive heart failure | 9(7.9) | 5(19.2) | 4(4.5) | 5.00(1.2–20.2) | 0.028 |  |  |
 Chronic obstructive pulmonary disease | 3(2.6) | 0(0) | 3(3.4) | NA | 1 |  |  |
 Malignancy | 59(51.8) | 11(42.3) | 48(54.5) | 0.61(0.3–1.5) | 0.273 |  |  |
 Immunosuppression | 26(22.8) | 6(23.1) | 20(22.7) | 1.02(0.4–2.9) | 0.97 |  |  |
 Charlson comorbidity index, median (IQR) | 3(2–6) | 3(2–6.75) | 3(1.25–6) | NA | 0.576 |  |  |
Probable source of infection | |||||||
 Lung | 16(14.0) | 9(34.6) | 7(8.0) | 6.13(2.0–18.7) | 0.002 | 4.23(1.0–17.3) | 0.045 |
 Intra-abdominal | 48(42.1) | 9(34.6) | 39(44.3) | 0.67(0.3–1.7) | 0.379 |  |  |
 Skin and soft tissue | 12(10.5) | 4(15.4) | 8(9.1) | 1.82(0.5–6.6) | 0.465 |  |  |
 Catheter-related | 10(8.8) | 2(7.7) | 8(9.1) | 0.83(0.2–4.2) | 1 |  |  |
Hospital events prior to onset of BSI | Â | Â | Â | Â | |||
 Exposure to antimicrobial therapy a | 74(64.9) | 20(76.9) | 54(61.4) | 2.10(0.8–5.8) | 0.144 |  |  |
 Surgery a | 62(54.4) | 15(57.7) | 47(53.4) | 1.19(0.5–2.9) | 0.700 |  |  |
Events on the onset of BSI | |||||||
 Acute kidney injury | 16(14.0) | 12(46.2) | 4(4.5) | 18.00(5.1–63.8) | <0.001 |  |  |
 Use of renal replacement therapy | 8(7.0) | 5(19.2) | 3(3.4) | 6.75(1.5–30.5) | 0.015 |  |  |
 Septic shock | 28(24.6) | 16(61.5) | 12(13.6) | 10.13(3.7–27.5) | <0.001 |  |  |
 Use of mechanical ventilation | 24(21.1) | 15(57.7) | 9(10.2) | 11.97(4.2–33.9) | <0.001 |  |  |
 Removal of the infectious source | 33(28.9) | 6(23.1) | 27(30.7) | 0.68(0.2–1.9) | 0.453 |  |  |
 SOFA score, median (IQR) | 3(1–6) | 9(4–13.5) | 2(1–4) | NA | <0.001 | 1.40(1.2–1.6) | <0.001 |
 Pitt bacteraemia score, median (IQR) | 1(1–2.25) | 5(2–7) | 1(1–2) | NA | <0.001 | - | - |
CRKP | 33(28.9) | 11(42.3) | 22(25.0) | 2.20(0.9–5.5) | 0.087 |  |  |
Appropriate empirical therapy | 78(68.4) | 14(53.8) | 64(72.7) | 0.44(0.2–1.1) | 0.069 |  |  |