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Table 2 Multivariable Cox-proportional hazard regression of risk factors for 7-day mortality and hospital mortality after BSI with ESBL-positive or -negative E. coli and K. pneumoniae

From: E. coli bacteremia in comparison to K. pneumoniae bacteremia: influence of pathogen species and ESBL production on 7-day mortality

Parameter

Parameter/ category

7-days mortality (stepwise)

In-hospital mortalitya

HR

CI95

P-value

HR

CI95

P-value

Interaction effect between pathogen species and ESBL-production

E. coli ESBL-negative

1 = Reference

 

0.947

1 = Reference

 

0.084

E. coli ESBL-positive

1.16

0.70–1.90

0.571

1.22

0.88–1.68

0.228

K. pneumoniae ESBL-negative

0.98

0.64–1.50

0.926

1.39

1.07–1.82

0.015

K. pneumoniae ESBL-positive

1.05

0.49–2.27

0.894

1.01

0.60–1.67

0.983

Comorbidities

Heart disease

1.55

1.09–2.21

0.014

1.23

0.97–1.56

0.087

Liver disease

1.96

1.40–2.74

<0.001

1.85

1.48–2.30

<0.001

Renal disease

2.86

1.99–4.10

<0.001

2.32

1.82–2.95

<0.001

Cancer/ immunological disease

1.66

1.21–2.28

0.002

1.58

1.28–1.95

<0.001

  1. ESBL extended-spectrum beta-lactamase, HR hazard ratio, CI95 95 % confidence interval, N.s. not significant
  2. aAnalyzing the same parameters as in 7-days mortality
  3. P-values <0.05 were considered statistically significant