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Table 1 Univariate analysis of 7 days mortality in patients with extended-spectrum beta-lactamase (ESBL)-positive or -negative E. coli and K. pneumoniae bloodstream infection (during hospitalization)

From: E. coli bacteremia in comparison to K. pneumoniae bacteremia: influence of pathogen species and ESBL production on 7-day mortality

Parameter

Survived until 7 days after BSI

Died within 7 days after BSI

7-days Mortality

P-value

Survived/ discharged after BSI

Died in-hospital after BSI

In-hospital Mortality

P-value

Number (%)

Number (%)

Number (%)

Number (%)

Patients

1.690 (100 %)

161 (100 %)

8.7 %

 

1485 (100 %)

366 (100 %)

19.8 %

 

K. pneumoniae

319 (18.9 %)

33 (20.5 %)

9.4 %

0.616

264 (17.8 %)

88 (24.0 %)

25.0 %

0.006

E. coli

1371 (81.1 %)

128 (79.5 %)

8.5 %

1221 (82.2 %)

278 (76.0 %)

18.5 %

ESBL-positive

219 (13.0 %)

25 (15.5 %)

10.2 %

0.357

183 (12.3 %)

61 (16.7 %)

25.0 %

0.028

Hospital mortality

205 (12.1 %)

161 (100.0 %)

44.0 %

<0.001

-

366 (100.0 %)

100.0 %

n.a.

Polymicrobial

198 (11.7 %)

27 (16.8 %)

12.0 %

0.061*

160 (10.8 %)

65 (17.8 %)

28.9 %

<0.001*

Age (years)a

65 (52–73)a

67 (57–76)a

n.a.

0.019*

65 (52–73)a

66 (54–74)a

n.a.

0.134*

Male

929 (55.0 %)

93 (57.8 %)

9.1 %

0.496

799 (53.8 %)

223 (60.9 %)

21.8 %

0.014

Hospital onset

746 (44.1 %)

84 (52.2 %)

10.1 %

0.050*

612 (41.2 %)

218 (59.6 %)

26.3 %

<0.001*

ICU stay

1.072 (63.4 %)

125 (77.6 %)

10.4 %

<0.001*

896 (60.3 %)

301 (82.2 %)

25.1 %

<0.001*

Charlson comorbidity indexa

5 (3–8)a

8 (6–10)a

n.a.

<0.001

5 (3–8)a

8 (6–10)a

n.a.

<0.001

Heart disease

275 (16.3 %)

47 (29.2 %)

14.6 %

<0.001*

215 (14.5 %)

107 (29.2 %)

33.2 %

<0.001*

Cerebrovascular disease

243 (14.4 %)

31 (19.3 %)

11.3 %

0.096*

202 (13.6 %)

72 (19.7 %)

26.3 %

0.003*

Neurologic disease

123 (7.3 %)

11 (6.8 %)

8.2 %

0.835

112 (7.5 %)

22 (6.0 %)

16.4 %

0.311

Lung disease

218 (12.9 %)

24 (14.9 %)

9.9 %

0.470

181 (12.2 %)

61 (16.7 %)

25.2 %

0.023

Gastrointestinal disease

53 (3.1 %)

12 (7.5 %)

18.5 %

0.004*

36 (2.4 %)

29 (7.9 %)

44.6 %

<0.001*

Rheumatic disease

50 (3.0 %)

2 (1.2 %)

3.8 %

0.208

44 (3.0 %)

8 (2.2 %)

15.4 %

0.420

Liver disease

258 (15.3 %)

53 (32.9 %)

17.0 %

<0.001*

180 (12.1 %)

131 (35.8 %)

42.1 %

<0.001*

Diabetes

422 (25.0 %)

48 (29.8 %)

10.2 %

0.177

366 (24.6 %)

104 (28.4 %)

22.1 %

0.138

Renal disease

711 (42.1 %)

115 (71.4 %)

13.9 %

<0.001*

565 (38.0 %)

261 (71.3 %)

31.6 %

<0.001*

Cancer/immunological disease

672 (39.8 %)

75 (46.6 %)

10.0 %

0.092*

571 (38.5 %)

176 (48.1 %)

23.6 %

0.001*

  1. BSI bloodstream infection, LOS length of stay, N.a. not applicable
  2. * Included in the multivariable Cox-proportional hazard regression
  3. a Continuous parameter displayed as median (interquartile range)
  4. P-values <0.05 were considered statistically significant