Variable, n (%) | ESBL+ infections (n = 110) | ESBL- infections (n = 76) | P-value |
---|---|---|---|
Demographics | Â | Â | Â |
 Male gender | 68(61.8) | 35(46.05) | 0.037 |
 Mean age, years (range) | 26.3(20.9–31.7) | 28.1(21.5–34.7) | 0.665 |
 Newborns (0–28 days) | 22(20.0) | 4(5.3) | 0.005 |
 Premature babies | 12(10.9) | 2(2.6) | 0.046 |
 Children (1 month-17 years) | 37(33.6) | 34(44.7) | 0.167 |
 Adults (up to 17 years) | 51(46.4) | 38(50.0) | 0.656 |
Comorbidity | Â | Â | Â |
 Sickle cell disease | 10(9.1) | 7(9.2) | 1 |
 Malnutrition | 10(9.1) | 7(9.2) | 1 |
 AIDS | 8(7.2) | 2(2.6) | 0.203 |
Diagnostic at admission | Â | Â | Â |
 Severe malaria | 19(17.3) | 7(9.2) | 0.808 |
 Gastroenteritis | 16(14.5) | 9(11.8) | 0.666 |
 Respiratory disease | 25(22.7) | 10(9.1) | 0.127 |
 Neurologic disorder | 20(18.2) | 12(15.8) | 0.698 |
 Meningitis | 10(9.1) | 5(4.5) | 0.596 |
 Tuberculosis | 3(2.7) | 3(3.9) | 0.689 |
 Cancer | 10(9.1) | 6(7.9) | 1 |
 Tetanus | 4(3.6) | 6(7.9) | 0.321 |
Invasive procedure | Â | Â | Â |
 Surgical intervention | 18(16.4) | 18(23.7) | 0.258 |
 Parental nutrition | 24(21.8) | 6(7.9) | 0.014 |
 Mechanical ventilation | 38(34.5) | 7(9.2) | <0.0001 |
 Central venous catheter | 84(76.4) | 35(46.0) | <0.0001 |
 Urinary catheter | 37(33.6) | 13(17.1) | 0.018 |
Type of infection | Â | Â | Â |
 Bloodstream infection | 49(44.5) | 20(26.3) | 0.013 |
 Urinary tract infection | 36(32.7) | 31(40.8) | 0.279 |
 Surgical site infection | 13(11.8) | 11(14.4) | 0.656 |
 Respiratory infection | 5(4.5) | 12(15.8) | 0.016 |
 Meningitidis | 7(6.4) | 2(2.6) | 0.313 |
Time to infection, in days (95%CI) | Â | Â | Â |
 All patients | 8.2(6.4–9.9) | 4.8(2.7–6.9) | 0.007 |
 Adults | 11.3(8.8–13.8) | 7.7(4.8–10.6) | 0.029 |
 Children | 6.6(3.1–10.2) | 2(1.2–5.2) | 0.028 |
 Newborns | 3.5(2.2–4.8) | 1(0.3–2.3) | 0.059 |
Mean time after infection, days (95 % CI) | Â | Â | Â |
 All patients | 14.2(12.6–16.3) | 9.3(7.4–11.1) | <0.0001 |
 Adults | 15.1(11.9–18.3) | 8.9(7.2–10.6) | 0.001 |
 Children | 15.5(12.3–18.7) | 10(6.3–13.7) | 0.013 |
 Newborns | 11.1(8.7–13.5) | 6.2(5.8–13.0) | 0.050 |
 Inadequate antibiotherapy prescription | 97(88.2) | 14(18.4) | <0.0001 |