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Table 4 Molecular characteristics of HR-GNR positive isolates

From: Prevalence, risk factors and molecular epidemiology of highly resistant gram negative rods in hospitalized patients in the Dutch region Kennemerland

Patient

Hospital

Species

MLST

HR-GNR typea, b, c

ESBL gene(s)

Acquired AMGdresistance genes

Acquired QUIeresistance genes

AMGdresistancef

QUIeresistancef

P1

1

E. coli

ST685

ESBL

CTX-M-1

-

-

S

S

P2

1

K. pneumoniae

ST48

ESBL

CTX-M-15, SHV-11

strA, strB

oqxA, oqxB, QnrB66

S

S

P3

1

E. coli

ST69

Q&A

-

strA, strB, aph(3’)-Ia, aadA5, aac(3)-IId

-

R

R

P4

2

E. coli

ST5929g

ESBL

CTX-M-1

-

-

S

S

P5

2

E. coli

ST69

ESBL

CTX-M-1

aadA5

-

S

S

P6

2

E. coli

ST2178

ESBL

CTX-M-3

-

-

S

S

  

E. coli

ND

ESBL

ND

ND

ND

S

S

  

K. pneumoniae

ST22

ESBL

CTX-M-15

strA, strB, aph (3’)-Ic, aac(3)-Iia, aac(6’) Ib-cr

oqxA, oqxB, aac(6’) Ib-cr, QnrB66

R

S

P7

2

E. coli

ST349

ESBL

CTX-M-14b

strA, strB

-

S

S

P8

2

E. coli

ST93

ESBL

CTX-M-14b

-

-

S

R

P9

2

E. coli

ST131

ESBL

CTX-M-27

strA, strB, aadA5

-

S

R

P10

2

E. cloacae

ST50

ESBL

CTX-M-1

aadA2, aadB

oqxA, oqxB, QnrA1

I

R

P11

2

E. cloacae

ST421g

ESBL

CTX-M-9

aadB

oqxA, oqxB, QnrA1

S

S

P12

2

E. cloacae

ST50

ESBL

CTX-M-9

aadA2, aadB

oqxA, oqxB, QnrA1

I

R

  

E. coli

ST88

Q&A

-

aph(3’)-Ic

-

R

R

P13

2

E. coli

ST69

Q&A

-

strA, strB, aac(3)-IId

-

R

R

P14

2

E. coli

ST131

Q&A

-

strA, aac(3)-Iid, aadA5

-

R

R

P15

2

E. coli

ST648

Q&A

-

aac(6’) Ib-cr

aac(6’) Ib-cr

R

R

P16

3

E. coli

ST10

ESBL

CTX-M-14

strA, strB, aac(3)-IId, aadA1, aadA4, aac(6’) Ib-cr

aac(6’) Ib-cr

R

S

P17

3

K. pneumoniae

ST45

ESBL

CTX-M-15

strA, strB, aac(3)-IIa, aac(6’) Ib-cr

oqxA, oqxB, aac(6’) Ib-cr, QnrB66

R

I

P18

3

E. coli

ST131

ESBL

CTX-M-27

-

-

S

R

P19

3

E. coli

ST635

ESBL

SHV-12

strA, strB, aac(3)-IIb, aacA4, aac(6’) Ib-cr, aac(6’)-IIc

aac(6’) Ib-cr, QnrB4, QnrB66

R

I

P20

3

E. coli

ST57

Q&A

-

aph(4)-Ia, aac(3)-IVa, aadA2

-

R

R

  

E. coli

ND

Q&A

-

ND

ND

R

R

P21

3

E. coli

ST131

Q&A

-

strA, strB, aac(3)-Iid, aadA5

-

R

R

P22

3

S. maltophilia

ST152g

CTX-R

-

aph(3’)-IIc, aacA4, aac(6’) Ib-cr

aac(6’) Ib-cr

ND

ND

  1. a: ESBL: Extended Spectrum Beta Lactamase; b: Q&A: combined resistance towards Fluoroquinolones and Aminoglycosides; c: CTX-R: resistance towards Co-trimoxazole; d: QUI: Fluoroquinolones; e: AMG: Aminoglycosides; f: resistance based on VITEK2 results; S sensitive, I intermediate, R resistant, ND not determined, NA not available, g new sequence type