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Table 2 Definition of Gram-negative multidrug-resistant organisms according to Dutch guideline

From: Cross-border comparison of the Dutch and German guidelines on multidrug-resistant Gram-negative microorganisms

Antibiotic, resistance mechanism

Enterobacteriaceae

Pseudomonas aeruginosa

Acinetobacter sp.

Stenotrphomonas maltophilia

Piperacillin

 

C

  

ESBL positive

A

   

Ceftazidime

 

C

  

Carbapenemase positive

A

C

A

 

Quinolones

B

C

B*

 

Aminoglycosides

B

C

B

 

Cotrimoxazole

   

A

  1. Definition of GN-MDRO, designated “BRMO”, is based on results of phenotypic susceptibility testing to four antibiotic classes (piperacillin, ceftazidime, quinolones, aminoglycosides and cotrimoxazole) and resistance mechanisms. A = Bacteria have to be resistant against this one antibiotic group to fulfil at the definition. B = Bacteria have to be resistant against a least two of these antibiotic groups to fulfil at the definition. C = Bacteria have to be resistant against at least three of these antibiotic groups to fulfil at the definition.
  2. *Except norfloxacin.