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Table 2 Estimated pneumonia burden due to antibiotic-resistant Streptococcus pneumoniae isolates

From: Attributable healthcare utilization and cost of pneumoniae due to drug-resistant Streptococcus pneumoniae: a cost analysis

 

Age (years)

 

0- < 5

5- < 18

18- < 50

50- < 65

65+

Total

Inpatient cases

N (% of total)

40,386 (10%)

16,772 (4%)

42,789 (11%)

59,508 (15%)

241,827 (60%)

401,282

Susceptible isolates (pre-2008 MIC)

32,963 (82%)

14,284 (85%)

38,329 (90%)

52,804 (89%)

215,160 (89%)

353,543

Susceptible isolates (post-2008 MIC)

36,799 (91%)

15,251 (91%)

40,877 (96%)

56,559 (95%)

231,704 (96%)

381,190

PCN resistant isolates (pre-2008 MIC)*

14,375 (36%)

3,522 (21%)

8,130 (19%)

12,497 (21%)

58,038 (24%)

96,562

PCN resistant isolates (post-2008 MIC)

4,846 (12%)

1,174 (7%)

1,711 (4%)

2,975 (5%)

12,901 (5%)

23,607

ERY resistant isolates

10,821 (26%)

3,250 (19%)

7,296 (17%)

10,811 (18%)

48,754 (20%)

80,932

FQ resistant isolates

404 (1%)

168 (1%)

428 (1%)

595 (1%)

2,616 (1%)

4,211

Multiply resistant isolates (pre-2008 MIC)

8,562 (21%)

2,084 (12%)

4,927 (12%)

7,603 (13%)

36,375 (15%)

59,551

Multiply resistant isolates (post-2008 MIC)

2,926 (7%)

716 (4%)

1,095 (3%)

1,893 (3%)

8,115 (3%)

14,745

Outpatient cases

N (% of total)

119,613(26%)

88,810 (19%)

116,427 (25%)

78,154 (17%)

61,519 (13%)

464,523

Susceptible isolates (pre-2008 MIC)

97,791 (82%)

72,608 (82%)

101,297 (87%)

67,216 (86%)

53,524 (87%)

392,436

Susceptible isolates (post-2008 MIC)

106,974 (89%)

79,427 (89%)

112,860 (97%)

74,729 (96%)

59,630 (97%)

433,620

PCN resistant isolates (pre-2008 MIC)

44,257 (37%)

32,860 (37%)

43,078 (37%)

28,917 (37%)

22,762 (37%)

171,873

PCN resistant isolates (post-2008 MIC)

14,354 (12%)

10,657 (12%)

9,314 (8%)

7,034 (9%)

4,922 (8%)

46,281

ERY resistant isolates

37,728 (32%)

28,012 (32%)

33,532 (29%)

22,509 (29%)

17,718 (29%)

139,499

FQ resistant isolates

1,196 (1%)

888 (1%)

1,164 (1%)

782 (1%)

681 (1%)

4,711

Multiply resistant isolates (pre-2008 MIC)

31,147 (26%)

23,126 (26%)

28,595 (25%)

19,195 (25%)

15,141 (25%)

117,204

Multiply resistant isolates (post-2008 MIC)

10,634 (9%)

7,895 (9%)

6,615 (6%)

4,968 (6%)

3,550 (6%)

33,662

  1. *In January 2008, the Clinical and Laboratory Standards Institute revised the minimum inhibitory concentration (MIC) for non-susceptibility to penicillin.
  2. Notes: PCN = penicillin, ERY = erythromycin, FQ = fluoroquinolone. “Resistant” includes intermediate and non-susceptible isolates. Data sources: Active Bacterial Core Surveillance data (inpatient) and primary literature (outpatient). Resistance categories are not mutually exclusive, as some strains exhibited resistance to multiple antibiotics.
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Antimicrobial Resistance & Infection Control

ISSN: 2047-2994

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