Antimicrobial susceptibility profiles of human and piglet Clostridium difficile PCR-ribotype 078

Table 2 Mechanisms of resistance found in C. difficile type 078 isolates

Antibiotic	Origin of isolate^a(total number)	Mechanism of resistance	N. of positive isolates (%)
Tetracycline	Human (6)	tet(M)	6 (100%)
Tetracycline	Porcine (8)	tet(M)	8 (100%)
Erythromycin	Human (29)	erm(B)	3 (10%)
Erythromycin	Porcine (38)	erm(B)	0 (0%)
Clindamycin	Human (3)	erm(B)	3 (100%)
Clindamycin	Porcine (1)	erm(B)	0 (0%)
Moxifloxacin	Human (8)	Aminoacid substitution in GyrA	8 (100%)
Moxifloxacin	Porcine (7)	Aminoacid substitution in GyrA	4 (57%)

^a: All isolates with tetracycline MIC ≥8 mg/L (n=14), erythromycin MIC ≥4 mg/L (n=67) or clindamycin MIC ≥4 mg/L (n=4) were analysed for resistance mechanisms. Seven of eight porcine isolates with moxifloxacin MIC ≥4 mg/L were tested for mutations.

ISSN: 2047-2994